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PT-141

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Other names:Bremelanotide,Vyleesi

AASraw is the professional manufacturer of peptide PT-141(Bremelanotide) which has independent lab and large factory as support,all production will be carried out under CGMP regulation and trackable quality control system.AASraw can accept the customized service according to specific requests on peptide raw powder or finished peptide vials.

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Product Description

What is PT-141(Bremelanotide)?

PT-141, also known as bremelanotide, is a generic name for a new class of peptides that are being studied to help improve sexual dysfunction (erectile dysfunction, or impotence) in men and to help improve sexual dysfunction (sexual arousal disorder) in women.[6]141 does not act on the vascular system like the previous two compounds, but it is known and has been shown to help increase sexual activity in both male and female mammals.[3][8][5] Moreover, peptide PT 141 is now FDA-approved to treat sexual dysfunction in women.[8][5] If people want to buy peptide PT 141 online, many sources, such as a PT 141 manufacturer and supplier, can be easily found.

How does PT-141(Bremelanotide) work?

PT-141 (Bremelanotide) is the first of an alternative class of drugs known as melanocortin agonists for therapeutic pathology.[1] The mechanism of action of PT-141 (Bremelanotide) may provide important safety and efficacy advantages compared to currently available products because it acts on pathways of control operations rather than directly on the system.[3] Clinical data show that PT-141 (Bremelanotide) can also effectively treat various impotence patients.[4] The nasal formulation of PT-141 (Bremelanotide) under development is as convenient as an oral therapy, is very patient-friendly compared to invasive treatments such as injections and transurethral pellets, and appears to have a rapid onset of action.[1]

Bremelanotide PT-141 is said to work by activating melanocortin receptors in the brain, thereby helping to increase sexual arousal. It is a melanocortin-based peptide that has shown effectiveness in clinical studies in male and female rats. Male rats showed erectile responses at doses as low as 1-2 mg, while most female rats showed positive responses at doses as high as 2-3 mg. Dosage requirements were higher for female rats, but stronger results were observed in female rats.

It is important to note that the mechanism of action of the product is related to its quality. Only high-quality products may have an ideal mechanism of action. To ensure the quality of PT-141, it is crucial to acquire it from a reliable source.AASraw, a reputable manufacturer and supplier of PT-141, offers high-quality peptide products for independent research and development centers and factories.If you have specific requirements, choosing to wholesale PT-141 from AASraw is an excellent option.

Benefits of using peptide PT-141(Bremelanotide)

PT-141 (Bremelanotide) offers primary benefits in treating sexual dysfunction in both men and women. When administered via injection, it has demonstrated particularly promising results in female test subjects. However, it also proves beneficial for males experiencing issues such as erectile dysfunction, low libido, and impotence.

Increase sexual desire

One of the key advantages of PT-141 is its ability to increase sexual desire through the central nervous system without adversely affecting the vascular system. In comparison to other sexual dysfunction medications, AASraw PT-141 is considered more potent while still maintaining a favorable safety profile. It does not pose significant risks to one’s overall health.[3][8]

In the treatment of sexual dysfunction, PT-141 has been shown to effectively boost sexual desire in women, and the effects can be long-lasting. Some individuals experience the benefits for up to 72 hours following the injection of PT-141.

Increase energy

In addition to its role in addressing sexual dysfunction, PT-141 has shown potential for naturally increasing energy levels. Men’s hormone clinics also employ PT-141 to address symptoms related to low testosterone. The peptide blend of PT-141 can be beneficial for individuals who frequently experience lethargy, fatigue, or a lack of energy.[7][3]

Treat skin pigmentation disorders.

Furthermore, PT-141 has been explored for its potential in treating skin pigmentation disorders and has been utilized as a natural, sunless tanning agent. However, the propensity of PT-141 to cause sexual arousal in users has limited its application in tanning products. It is essential to note that the primary purpose of using PT-141 remains the treatment of various dysfunctions and the enhancement of sexual desire in both men and women.

It is key to buy PT-141 from reputable sources; otherwise, you cannot get the best efficacy from PT-141. As a professional PT-141 manufacturer and supplier, AASraw aims to supply pure PT-141 worldwide. If you have needs, AASraw’s peptide PT-141 is a great choice for you.

Side effects of peptide PT-141(Bremelanotide)  

While PT-141 (Bremelanotide) is generally well tolerated, it is important to be aware of potential side effects that may occur. Some of the possible side effects of PT-141 include:

Nausea: Nausea is one of the most commonly reported side effects of PT-141.It may cause feelings of queasiness or an upset stomach.

Headache: Some individuals may experience headaches as a side effect of PT-141.These headaches are typically mild and resolve on their own.

Injection site reactions: Since PT-141 is administered via injection, there is a possibility of experiencing injection site reactions such as pain, redness, or swelling at the injection site.

Dizziness: Dizziness or lightheartedness may occur as a side effect of PT-141.It is important to avoid activities that require alertness if you experience dizziness.

Fatigue: Some individuals may experience fatigue or tiredness after taking PT-141.

Nasal congestion: If PT-141 is administered in nasal spray form, nasal congestion or stuffiness may occur as a side effect.

It is important to note that not everyone will experience these side effects, and the severity and frequency of side effects may vary among individuals. If you experience any concerning or persistent side effects, it is recommended that you consult with a healthcare professional for further guidance. Furthermore, when buying PT-141, you need to carefully choose the PT-141 supplier to ensure the quality of the product. At the same time, it needs to be used under the guidance of professionals to avoid adverse consequences.[2][7][3]

PT-141 vs Melanotan II (MT-2)

PT-141 (Bremelanotide) and Melanotan II (MT-2) have some differences in their effects and mechanisms of action when it comes to the treatment of erectile dysfunction (ED). Here’s a comparison between PT-141 and MT-2 regarding their effects on ED.

①Mechanism of Action

PT-141

PT-141 primarily acts on the central nervous system by targeting melanocortin receptors, particularly the melanocortin 4 receptor (MC4R) in the brain. It stimulates the release of nitric oxide, which helps relax smooth muscles in the penis and increase blood flow, leading to improved erectile function.

Melanotan II

Melanotan II primarily works by targeting melanocortin receptors, particularly the melanocortin 1 receptor (MC1R). Its primary purpose is to stimulate the production of melanin in the skin, resulting in skin darkening. While it may have some impact on sexual function, its effects on erectile function are less direct compared to PT-141.

②Focus on Erectile Dysfunction

PT-141

PT-141 has been specifically studied and developed for the treatment of sexual dysfunction, including erectile dysfunction, in both men and women. Clinical trials have shown promising results in improving erectile function and sexual desire.

Melanotan II

While Melanotan II has been reported anecdotally to have some effects on sexual function and libido, its primary purpose is not focused on treating erectile dysfunction. It is primarily used for tanning effects and has limited clinical evidence supporting its use in treating ED.

③Clinical Evidence

PT-141

PT-141 has undergone clinical trials specifically evaluating its efficacy in treating erectile dysfunction. These trials have shown positive results, indicating its potential as a treatment option for ED.

Melanotan II

Melanotan II has limited clinical evidence supporting its effectiveness in treating erectile dysfunction. Most of the available data on its effects on sexual function is based on anecdotal reports rather than rigorous clinical studies.

In summary, PT-141 has been more extensively studied and developed for the treatment of erectile dysfunction and sexual dysfunction in both men and women. Its mechanism of action directly targets the central nervous system and has shown promising results in clinical trials. On the other hand, Melanotan II primarily focuses on skin darkening and has less direct evidence for its effectiveness in treating erectile dysfunction.

Where to Buy PT-141(Bremelanotide)?

When it comes to PT-141 (Bremelanotide), it is crucial to prioritize safety and authenticity when considering a purchase from online suppliers. Authentic and reliable sources should be sought to ensure the quality and effectiveness of the product for its intended health applications. Verification of the supplier’s reputation is important, as is their adherence to quality control standards and the provision of necessary documentation such as a Certificate of Analysis.[1][3]

If you’re seeking a reliable source for buying PT-141, AASraw may be a suitable option.AASraw is a company that offers a wide range of peptides, including PT-141. Their products are typically used by laboratories and research institutions for the development and production of various health products.

PT-141 Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? 
H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure. For 
example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR 
can(either be used to match against spectral libraries or to infer the basic structure directly. Once the
basic structure is known, NMR can be used to determine molecular conformation in solution as well as 
studying physical properties at the molecular level such as conformational exchange, phase changes,
solubility, and diffusion.

How to buy PT-141 from AASraw?

❶To contact us by our email inquiry system, or leave your WhatsApp number to us, our customer service representative(CSR) will contact you in 12 hours.

❷To provide us with your inquired quantity and address.

❸Our CSR will provide you with the quotation, payment term, tracking number, delivery ways, and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Anita H. Clayton MD
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia
2. François Giuliano MD, PhD
Raymond Poincaré Hospital—Department of Physical Medicine and Rehabilitation, Garches, France
3. Mohammad Reza Safarinejad
Urology and Nephrology Research Center, Shaheed Modarress Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
4. Raymond C. Rosen PhD
Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1].Simon JA,Kingsberg SA”Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder.”Obstet Gynecol.2019 Nov.PMID:31599847.

[2] Diamond LE,Earle DC,Heiman JR,Rosen RC,Perelman MA,Harning R.”An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141),a melanocortin receptor agonist.”J Sex Med.2006 Jul; PMID:16839319.

[3] Ückert S,Bannowsky A,Albrecht K,Kuczyk MA (November 2014).”Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions:results from basic research and clinical studies”.Expert Opinion on Investigational Drugs.23 (11):1477–83.doi:10.1517/13543784.2014.934805.PMID 25096243.

[4] Pfaus J,Giuliano F,Gelez H.”Bremelanotide:an overview of preclinical CNS effects on female sexual function.”J Sex Med.2007 Nov.PMID:17958619.

[5] Mintzes B,Tiefer L,Cosgrove L.”Bremelanotide and flibanserin for low sexual desire in women:the fallacy of regulatory precedent.”Drug Ther Bull.2021 Dec;PMID:34642243.

[6] Molinoff PB,Shadiack AM,Earle D,Diamond LE,Quon CY.”PT-141:a melanocortin agonist for the treatment of sexual dysfunction”Ann N Y Acad Sci.2003 Jun.PMID:12851303.

[7] Rosen RC,Diamond LE,Earle DC,Shadiack AM,Molinoff PB.”Evaluation of the safety,pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141,a melanocortin receptor agonist,in healthy male subjects and in patients with an inadequate response to Viagra.”Int J Impot Res.2004 Apr.PMID:14999221.

[8] Diamond LE,Earle DC,Garcia WD,Spana C.”Co-administration of low doses of intranasal PT-141,a melanocortin receptor agonist,and sildenafil to men with erectile dysfunction results in an enhanced erectile response.”Urology.2005 Apr;PMID:15833522.


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