Pregabalin powder

Basic Characters

What is pregabalin powder?

Pregabalin powder is a gabapentin-class medication that works by inhibiting specific calcium channels. Pregabalin powder was initially designed to treat epilepsy because its mechanism of action is similar to that of gabapentin, which can prevent seizures by modulating voltage-dependent calcium channels in the central nervous system. In clinical trials, however, researchers discovered that it is also quite efficient in pain management. Pregabalin powder reduces neuropathic pain, diabetic peripheral neuropathy, and other symptoms by boosting GABA levels in the body and suppressing the release of excitatory neurotransmitters. Pregabalin powder can also be used to treat a number of pain conditions, including fibromyalgia and postherpetic neuralgia. As a result, pregabalin powder is widely utilized in the treatment of various forms of pain and has emerged as a key medicine in the clinical treatment of neuropathic pain.

How does pregabalin work on the body?

Pregabalin’s mechanism of action is similar to that of gabapentin, and it has demonstrated anticonvulsant and analgesic effects in many animal models, although the precise mechanism of action remains unknown. Pregabalin is structurally similar to the neurotransmitter GABA; however, it does not work in the same way. This medicine, however, differs from standard antiepileptic drugs. Within the effective concentration range, it has no effect on GABAA or GABAB receptors. It is not converted into GABA or a GABA agonist, nor does it inhibit GABA uptake and degradation, nor does it act on sodium or calcium channels, nor does it decrease glutamate release and uptake.

Pregabalin powder, on the other hand, has no affinity for glutamic acid, GABA, or other active amino acid receptors, but it can substitute the binding of tagged GABA to calcium ion channel 2 and subreceptors and inhibit the central nervous system. A subunit 2-protein of voltage-dependent calcium channels that inhibits calcium ion influx, lowering the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P and influencing GABAergic neurotransmission. Furthermore, pregabalin can dramatically raise GABA levels in the body, and increasing the dose of pregabalin can significantly increase glutamic acid decarboxylase activity.

History of Using Pregabalin Powder

In the 1950s, scientists identified another inhibitory neurotransmitter known as gamma-aminobutyric acid, or GABA for short. GABA is a neurotransmitter that operates on GABA receptors in the human body. People hypothesize that low GABA may cause epilepsy and that GABA may also be associated with pain because of its inhibitory impact. The discovery of GABA and the clarification of its potential drug-making mechanism resulted in the development of novel anti-epileptic medicines, the most well-known of which is pregabalin.

Pregabalin powder is a drug used to treat a variety of conditions, including diabetic peripheral neuralgia, postherpetic neuralgia, fibromyalgia, and neuropathic pain from spinal cord injuries in adults, among others. Since the discovery of pregabalin, its development and application have been continuously carried out.

√ In August 2003, Pfizer first filed an application for registration in the United States.

√ In December 2004, the US FDA approved pregabalin for diabetic peripheral neuralgia and postherpetic neuralgia.

√ In June 2005, pregabalin was approved as an adjunct drug in the treatment of partial-onset seizures.

√ In June 2007, pregabalin was approved by the US FDA as the first drug for the treatment of fibromyalgia syndrome.

√ In June 2012, the FDA approved pregabalin as the first drug to treat neuralgia caused by spinal cord injury.

√ In March 2019, pregabalin was officially used for the treatment of fibromyalgia in China.

So far, pregabalin has been approved for the treatment of neuropathic pain in more than 40 countries, including Europe, Canada, and Mexico.

Although pregabalin powder is widely available worldwide, it is important to exercise caution when considering buying pregabalin and only buy it from reputable sources. Many pregabalin manufacturers and suppliers claim they supply pregabalin of high quality, but not all the pregabalin powders are authentic. Purchasing medications from unverified sources or online marketplaces can be risky and may result in receiving counterfeit or substandard products.

Benefits of Using Pregabalin Powder

Pregabalin powder is a versatile medication that offers a range of benefits for individuals with various medical conditions. Some of the most common conditions that can benefit from the use of AASraw pregabalin powder include diabetic peripheral neuropathy, postherpetic neuralgia, partial epilepsy, fibromyalgia, neuropathic pain, and generalized anxiety disorder.

· Diabetic Peripheral Neuropathy (DPN)

Diabetic peripheral neuropathy (DPN) is a common consequence of both type 1 and type 2 diabetes, affecting around 30–40% of diabetics. Symptoms of this nerve condition in the hands and feet include pain, weakness, and loss of sensation. Pregabalin powder is the first-line medication for DPN, offering significant pain relief while also addressing comorbidities like anxiety and insomnia. More research is needed, however, to completely understand pregabalin’s therapeutic effects on anxiety and sleep disorders, as well as to discover which individuals would benefit the most from this medication.

· Postherpetic Neuralgia (PHN)

Postherpetic neuralgia (PHN) is a debilitating chronic pain syndrome that can develop after a herpes zoster epidemic and becomes more common as patients age. PHN can be difficult to treat and frequently necessitates the use of multiple medicines in order to get meaningful pain reduction. Pregabalin powder is the most recent drug to be approved for PHN. Data demonstrate efficacy for pain alleviation and sleep disruption caused by PHN in affected patients. Although there have been no direct comparisons, pregabalin looks to be equivalent to gabapentin and other first-line medications for the treatment of PHN.

· Partial Epilepsy

Pregabalin powder has been licensed and marketed as an antiepileptic drug for use as an adjunctive treatment of partial epilepsy. It acts at presynaptic calcium channels, modulating neurotransmitter release in the CNS. Three multi-center randomized, double-blind, placebo-controlled trials enrolling patients with refractory partial epilepsy have demonstrated an antiepileptic effect of pregabalin against placebo as adjunctive therapy, with 31-41% of patients showing a 50% reduction in seizure frequency.

· Fibromyalgia

Pregabalin powder is expected to alleviate fibromyalgia pain by limiting sensory propagation of nociception via calcium channel blockage and neurotransmitter release in the ascending pain pathway. Pregabalin has also been demonstrated to lower glutamate and glutamine levels in the posterior insula of fibromyalgia patients, interfering with its functional connection to the default mode network.

Occipital nerve stimulation (ONS) studies on fibromyalgia patients demonstrate impaired conditioned pain modulation. Pregabalin has been demonstrated to have impacts on descending pain circuitry in nerve-injured rats; thus, pregabalin’s central effects may contribute to its efficacy in treating fibromyalgia.

· Neuropathic Pain

Pregabalin powder is a voltage-gated Ca2+ channel antagonist that binds exclusively to the alpha-2-delta subunit to generate analgesic effects. It effectively cures the symptoms of numerous types of neuropathic pain and has evolved into a first-line therapy medicine with high safety and efficacy. It has been proven in preclinical research in numerous animal models of neuropathic pain to be useful in the treatment of symptoms such as allodynia and hyperalgesia.

· Generalized Anxiety Disorder (GAD)

Studies have shown that pregabalin is consistently efficient in treating generalized anxiety disorder (GAD). In a critical review, seven out of eight randomized and controlled trials reported statistically significant reductions in Hamilton Anxiety Rating Scale scores with pregabalin powder doses ranging from 150 to 600 mg. In a separate study involving GAD patients who received pregabalin powder treatment for 12–24 weeks, the incidence of withdrawal symptoms and rebound anxiety after discontinuation was low. Pregabalin powder can also be an effective treatment option for patients with GAD who have not responded well to antidepressant therapy.

Precaution: Because the actual efficacy of pregabalin is related to the product’s quality, it is crucial to buy high-quality pregabalin powder. Pregabalin raw powder supplier AASraw manufactures and supplies pregabalin raw powder with strict production standards. If you need it, AASraw’s pregabalin powder is a good choice.

What Are the Side Effects of Using Pregabalin Powder?

The side effects of pregabalin powder are similar to those of other central nervous system depressants. Adverse drug reactions related to the use of pregabalin include:

· Very common (>10%):

Dizziness

Somnolence

· Common (1-10%):

Blurred vision

Diplopia

Euphoria

Confusion

Increased appetite and subsequent weight gain

· Uncommon (0.1–1%):

Hypoglycemia

Rash

Muscle cramps

Myalgia

Arthralgia

Thrombocytopenia

Kidney stones

Precaution: If the side effects do not gradually decrease or disappear, seek medical attention promptly. Besides, please ensure to buy qualified products to reduce side effects.

Dosage and Administration of Pregabalin Powder for Reference

Here is a chart of the recommended dosage of pregabalin powder for different medical conditions:

Precaution: It is important to note that these dosages are general guidelines and may vary based on individual factors, such as age, weight, and medical history. Additionally, the dosage may need to be adjusted over time based on the individual’s response to the medication and any side effects they may experience. It is important to consult with a healthcare provider to determine the appropriate dosage for each specific medical condition.

Where to buy Pregabalin Powder?

Pregabalin is available both online and offline, but you have to choose your suppliers carefully to ensure you are getting pure pregabalin powder. When choosing a supplier for pregabalin powder, there are several important factors to consider. First and foremost, it is crucial to ensure that the supplier is reputable and trustworthy. Look for suppliers who have a track record of providing high-quality products and reliable customer service. Additionally, you may want to consider factors such as the minimum order quantity, delivery times, and payment options. Finally, it is a good idea to read reviews and ask for recommendations from other customers to get an idea of the supplier’s reputation and level of customer satisfaction. By taking these factors into account, you can choose a pregabalin powder supplier that meets your needs and provides high-quality products and services.

AASraw is one of the most well-known manufacturers and suppliers of pregabalin powder, which is committed to providing high-quality, pure pregabalin powder to customers around the world. Besides, AASraw has a team of experienced professionals to ensure that all our products meet the highest standards of quality and purity. Moreover, AASraw uses advanced technology and equipment to manufacture pregabalin powder that is free from impurities and contaminants. Finally, AASraw has a strict quality control process in place to ensure that every batch of pregabalin powder is thoroughly tested for purity and potency.

Raw Pregabalin Powder Testing Report- HNMR

What is HNMR and What does HNMR spectrum tell you? 

H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure. For 
example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR 
can(either be used to match against spectral libraries or to infer the basic structure directly. Once the
basic structure is known, NMR can be used to determine molecular conformation in solution as well as 
studying physical properties at the molecular level such as conformational exchange, phase changes,
solubility, and diffusion.

Pregabalin Powder( 148553-50-8)-COA

Pregabalin Powder( 148553-50-8)-COA

How to buy pregabalin powder from AASraw?

❶To contact us by our email inquiry system, or leave your WhatsApp number, our customer service representative(CSR) will contact you in 12 hours.

❷To provide us with your inquired quantity and address.

❸Our CSR will provide you with the quotation, payment term, tracking number, delivery ways, and estimated arrival date(ETA).

❹Payment is done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Alexandra M. Stein
Orthopedics department, Hôpital Cochin Paris, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France
2. Tomoya Akashi
Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
3. H.R. Martínez
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey N.L., Mexico
4. Markus Dold
4.Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

Reference

[1] M.C. Walker, J.W. Sander. Difficulties in extrapolating from clinical trial data to clinical practice: the case of antiepileptic drugs. Neurology, 49 (1997), pp. 333-337

[2] M.J. Field, R.J. Oles, L. Singh. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br J Pharmacol, 132 (2001), pp. 1-4

[3] Hong JS, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. (March 2022). “Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale”. Molecular Psychiatry. 27 (3): 1339–1349.

[4] Freynhagen R, Baron R, Kawaguchi Y, Malik RA, Martire DL, Parsons B, et al. (January 2021). “Pregabalin for neuropathic pain in primary care settings: recommendations for dosing and titration”. Postgraduate Medicine. Informa UK Limited. 133 (1): 1–9.

[5] Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N (February 2019). “Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis” (PDF). Lancet. 393 (10173): 768–777.

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