Product Description
Raw Tesofensine Powder Basic Characters
| Product Name | Tesofensine powder |
| CAS No. | 195875-84-4 |
| Molecular Formula: | C17H23Cl2NO |
| Molecular Weight: | 328.28 |
| Boiling Point: | 396.6±42.0 °C |
| Color: | White powder |
| Storage Temp: | Store at -20°C |
What is Tesofensine powder?
Tesofensine (TE) inhibits the presynaptic reuptake of the neurotransmitter’s noradrenaline,dopamine and serotonin.Other types of selective serotonin reuptake inhibitors are used to treat depression and eating disorders,but they have generally failed to produce sustained weight loss.Sibutramine,in addition to its effect on serotonin,also inhibits the reuptake of other monoamines and has been shown to enhance postprandial satiety,reduce total calorie intake and to diminish the decline in energy expenditure usually associated with a diet-induced negative energy balance.
Tesofensine (TE) was originally studied for its effect on Parkinson’s and Alzheimer’s.Unfortunately,its exploration for these indications were limited because the patients were starting to lose too much weight.Since then,tesofensine has been studied as a way to treat obesity via its ability to reduce appetite.TE indirectly stimulates the cholinergic system and showed to be more successful than average weight loss remedies .
Tesofensine increases near transmission of a reuptake inhibitor 3 monoaminergic neurotransmitters in the brain.These neurotransmitters are serotonin,norepinephrine,and dopamine which help regulate energy balance and are linked to obesity and depression.On average,according to research,its 6-month weight loss results from research trials resulted in a weight loss of around 25 pounds.
The history of Tesofensine
Tesofensine was developed by a Danish pharmaceutical company as a modern treatment for obesity.However,in its first stages,it was used to treat neurological disorders such as Parkinson’s and Alzheimer’s.The reuptake inhibitor,tesofensine,decrease the loss of serotonin,noradrenaline,and dopamine which controls appetite,energy,and depression,all resulting in weight gain.More recently,tesofensine was approved by the FDA as an anti-obesity medication and has been used successfully since for weight loss reduction.
How does Tesofensine work?
Tesofensine powder from AASraw help to suppress appetite and boost metabolic rate.Studies prove tesofensine’s effectiveness in treating obesity.
One study found that participants all saw a noticeable difference when taking tesofensine,including an overall 5-10% reduction in body weight.
Everything from body fat to waist and hip circumference was also reduced,as was BMI.
From what research shows so far,tesofensine results go beyond weight loss benefits.Some of its reported effects include improved cognition,memory,and learning,which is why the peptide is also studied for its effects on depression and cognitive decline.
It’s important to emphasize that the benefits of tesofensine should be evaluated in the context of comprehensive lifestyle changes,including a balanced diet and regular physical activity.
Is Tesofensine Effective?
In a double-bind trial with 203 people (with half given a placebo) those taking the placebo had lost 2.[1]0% of body weight while those taking the medication with the active ingredient had experienced far more successful results.[3][2]For those taking the lowest dose of 0.25 mg,average weight loss was 6.5%,those taking the medium dose of 0.5% lost 11.2% and those taking the highest dose of 1 mg lost 12.6%.In the two highest dose groups,the treatment led to a 4 point drop in BMI in a period of 24 weeks.
Patients being treated with Tesofensine also displayed the following positive results:
Reduction in appetite sensations within a period of 14 days,with those being treated reporting a greater level of satiety and less desire to eat.
Significant increase in fat oxidation and reduction in fat tissue.The 24 hour fat oxidation increased by 15% and there was a reduction in protein oxidation.Scanning was able to provide confirmation of a statistically significant reduction in fat tissue compared with the placebo control group.
Improved levels of insulin sensitivity were noted,leading to a higher metabolism of glucose,making this medication potentially suitable for patients at risk from type II diabetes.
After 14 days,a significant increase in energy expenditure at rest of 6% was observed compared with the placebo control group.This increase was directly linked to Tesofensine and any external factors were excluded as possible causes.
Key Benefits of Tesofensine
Tesofensine for Weight Loss
Since discovering its ability to suppress appetite and aid in fat oxidation,researchers have diligently investigated the tesofensine obesity treatment.
The clinical Phase 2B trial results[ii] indicate that tesofensine produces approximately 28.2 lbs of weight loss on a 1 mg dose,24.9 lbs on a 0.3 mg dose,and 14.7 lbs on a 0.25 mg dose.All patients were instructed to follow a 300-calorie deficit diet and to engage in 30-60 minutes of physical exercise per day.
Research shows that tesofensine produced the best results when paired with caloric restrictions and exercise.
Other tesofensine results noted by patients include improved levels of insulin sensitivity,appetite reduction,an increase in energy after 14 days,and an increase in fat oxidation – and ultimately a reduction in fat tissue.
In the phase 3 study,a 24-week double-blinded trial,patients were given 0.25mg and 0.50mg of oral tesofensine.Results found a decrease in body weight,reduction in BMI,decreased body fat,decreased insulin,and improvements in hip and waist circumference.There was even evidence to suggest that tesofensine pills or capsules could better regulate glucose metabolism and even potentially reverse early type 2 diabetes.[2]
From what’s been discovered at present,this peptide looks to be a ground-breaking formula when it comes to the treatment of obesity and diabetes.
Tesofensine for Depression
According to research,tesofensine may be helpful for depression.Research demonstrates that stress can decrease BDNF levels in the brain – that is responsible for stimulating neuron growth and easing symptoms in those with depression and cognitive decline.When this exposure to stress becomes chronic and prolonged,atrophy of the hippocampus can occur.This change in the structure of the hippocampus has been linked to depression.
Studies show that tesofensine can improve BDNF levels and ultimately promote neurogenesis in the brain,offering anti-depressant properties.While it’s not been the primary focus of research,it’s clear that tesofensine capsules can be effective at easing mental health issues like depression.
Tesofensine for Alzheimer’s
While researchers may have abandoned the use of tesofensine in the treatment of Alzheimer’s and Parkinson’s,there’s still enough evidence to show the compound boasts beneficial effects on memory and cognition.Despite the dopamine-boosting effects being too small to have a great impact on these neurological diseases,some scientists are still interested in harnessing the peptide’s cognitive-enhancing abilities.
As previously mentioned,tesofensine peptide can increase BDNF levels.This,in turn,can help boost cell survival and reproduction.Experts are convinced this compound may be helpful for a range of conditions,including depression,obsessive-compulsive disorder,and Alzheimer’s.
Tesofensine for Pain Management
While research is limited on these effects,there is evidence to suggest that this anti-depressant may be able to help when it comes to managing pain.Thanks to dopamine-boosting agents,tesofensine may aid in quelling pain.Of course,the current research focus is on its ability to boost weight loss.That said,scientists do believe they’ll find more benefits of tesofensine the more they investigate the compound..
What are the side effects of Tesofensine
Is tesofensine a safe medication? Tesofensine’s side effects are similar to those of other dietary supplements and weight reduction drugs.The most prevalent tesofensine peptide adverse effects in clinical studies were dry mouth,nausea,sleeplessness,constipation,diarrhea,and elevated blood pressure.
Anti-obesity medications are recognized to pose cardiovascular hazards,according to experts.Tesofensine,on the other hand,is reasonably safe in comparison to many of these medicines.It is distinctive in that it targets neurotransmitter reuptake rather than the peripheral effect of lipase inhibitors and other drugs.
Is tesofensine harmful? According to what experts have learned thus far,it is not detrimental to health.[3]
FAQs
Does tesofensine burn fat?
According to preliminary study,tesofensine may be an efficient technique to lose body fat.Tesofensine has been demonstrated in studies to reduce food intake,resulting in lower calorie consumption and weight reduction.Furthermore,due to its potential to boost energy expenditure and fat oxidation,this medication appears to have anti-obesity properties.Tesofensine has the potential to be employed as an additional treatment for persons wishing to reduce weight as a result of these activities.While additional study into the long-term safety and usefulness of this medicine is needed,early indications indicate that it might be a beneficial tool for people who struggle with their weight.
Is tesofensine a peptide?
Tesofensine is not a peptide,but rather a novel,non-peptide triple monoamine reuptake inhibitor.It works by inhibiting the reuptake of the three major neurotransmitters (serotonin,noradrenaline,and dopamine) into the brain’s nerve cells.This allows for increased levels of these neurotransmitters in the brain which can lead to improved mental functioning and enhanced mood.Studies have also found that tesofensine leads to significant weight loss when combined with lifestyle changes such as healthy eating and exercise.In a clinical trial involving 67 obese patients,those taking tesofensine lost an average of 6.2% of their body weight over eight weeks compared to 0.7% body weight loss in those not taking it.While this evidence shows that tesofensine may help with weight loss,further research needs to be conducted to determine its long-term effects on health.
How long does tesofensine take to work?
Patients using Tesofensine showed the following good results: Reduction in hunger feelings during a 14-day period,with those receiving treatment experiencing better fullness and less desire to eat.
What Is the right dosage?
Depending on your current body fat percentage and weight loss goals will determine which dosage is right for your treatment.
Where to buy Tesofensine powder?
When it comes to purchase Tesofensine online,it’s important to buy from a reliable supplier who can guarantee the quality and authenticity of the product.At AASraw,we are a trusted Tesofensine manufacturer and supplier.
AASraw is proud to offer tesofensine as a viable solution for weight loss,thanks to its revolutionary new formula.Tesofensine has been clinically proven to be a safe and effective supplement for those looking to shed extra pounds.[3][1]
If you’re looking for a reliable supplier of high-quality tesofensine powder,look no further than AASraw.Contact us today to learn more about our products and services,and to place your order for wholesale tesofensine powder.
Tesofensine Powder Testing Report-HNMR
What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can(either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.
How to buy Tesofensine Powder from AASraw?
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Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine
Scientific Journal paper Author:
1. Majbrit M. Jensen
Neurobiology Research Unit, Copenhagen University Hospital – Rigshospitalet, DK-2100 Copenhagen, Denmark
2. Kora de Bruin
Department of Nuclear Medicine, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
3. Gitte Hansen
Rheoscience A/S, DK-2610 Roedovre, Denmark
4. Prof Sten Madsbad MD
Department of Endocrinology, University of Copenhagen, Denmark
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.
Reference
[1] Jorgen Scheel-Kruger,Peter Moldt,Frank Watjen.Tropane-derivatives,their preparation and use.U.S.Patent 6,288,079.
[2] Doggrell SA.”Tesofensine – a novel potent weight loss medicine.Evaluation of: Astrup A,Breum L,Jensen TJ,Kroustrup JP,Larsen TM.Effect of tesofensine on bodyweight loss,body composition,and quality of life in obese patients: a randomised,double-blind,placebo-controlled trial.Lancet 2009 372; 1906–13″ Doggrell SA (July 2009).Expert Opinion on Investigational Drugs.18 (7): 1043–6.doi:10.1517/13543780902967632.PMID 19548858.
[3] Schoedel KA,Meier D,Chakraborty B,Manniche PM,Sellers EM (July 2010).”Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users”.Clinical Pharmacology and Therapeutics.88 (1): 69–78.doi:10.1038/clpt.2010.67.PMID 20520602.S2CID 39849071.
