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Liraglutide

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Specification: Liraglutide 3MG, Liraglutide 10MG

AASraw is the professional peptide contract development and manufacturing organization (CDMO) for liraglutide, providing customized service tailored to meet specific client needs. Welcome to contact with us for more details!

WARNING: This product is for research use only.

 

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Product Description

Raw Liraglutide Basic Characters

Product NameLiraglutide
CAS No.204656-20-2
Molecular Formula:C172H265N43O51
Molecular Weight:3751 g/mol
Melting Point:NA
Color:White lyophililzed powder
Storage Temp:2°C-8°C

What is Liraglutide?

Liraglutide is a synthetic peptide that often used to treat type 2 diabetes and promote weight loss. Belongs to GLP-1 receptor agonists drug class, liraglutide is sold under the brand name Victoza and Saxenda. Victoza is approved for treating type 2 diabetes in 2009 while Saxenda is approved for chronic weight management in 2014. The Liraglutide is the active ingredient of the drugs.

Generic Liraglutide for sale

Liraglutide’s patent is in the process of expiring, but Generic Victoza was available in the market in June, 2024. A generic medication is a drug produced by compound companies when the brand-name drug’s patent expired. Generic Liraglutide has same active ingredient with branded drug, and same effectiveness. Generic liraglutide cost is often affordable than the brand-name drug. You can choose to buy affordable Generic Liraglutide from compounding pharmacies or peptides manufacturer.

What is Liraglutide used for?

Liraglutide was approved for treating type 2 diabetes and chronic weight management. But the conditions use this GLP-1 receptor agonist is different.

①Liraglutide for type 2 diabetes

Liraglutide is the second GLP-1 receptor agonist to be approved for type 2 diabetes. The brand name of Liraglutide got approved for type 2 diabetes treatment is Victoza. Adults and children aged over 10 years old can buy Liraglutide (Victoza) to use. Liraglutide can help patients control blood sugar levels, especially after you eat to reduce postprandial glucagon levels.

②Liraglutide for weight loss

The brand name of Liraglutide got approved for chronic weight management is Saxenda. Adults are obesity (BMI≥30) and overweight (BMI≥27) can buy prescription Liraglutide from Doctor. By taking Liraglutide for weight loss, it helps you to reduce appetite and food intake, leading to significant weight loss. Average, people taking Liraglutide 3mg for weight loss can lose 5% to 10% of their body weight over 6 to 12 months with the medication alone.

How does it work?

The GLP-1 drug’s mechanism are same. Liraglutide work similar with Semagltuide. It works by mimics the body natural hormone glucagon-like peptide-1 to control the blood sugar and appetite.

①The way Liraglutide controls blood sugar

After you eat, your blood sugar levels will rise, Liraglutide signals the pancreas to release insulin to lower blood sugar.

When the body suffer low blood sugar level, in order to keep level stable, your body automatically produce glucagon to raise it. At this time, Liraglutide work to suppress glucagon production to keep low blood sugar.

②The way Liraglutide slows down digestion

By binding to GLP-1 receptors on the smooth muscle of the stomach, Liraglutide slow down food digestion in your stomach, making you feel fuller longer time, leading to reduced food intake, thus help with weight loss.

③The way Liraglutide reduces appetite

Liraglutide acts on the hypothalamus in the brain to reduce appetite and cravings, making you feel full and eat less.

What benefits can you get from Liraglutide?

Like semaglutide, Liraglutide is a GLP-1 drug, here are the main benefits you will get:

①To control blood sugar

Liraglutide is a very effective drug to lower blood sugar levels by promoting Insulin release and suppressing Glucagon production at the same time. Patients with type 2 diabetes can buy Liraglutide to use.

②To lose weight

Many Clinical trials including SCALE Obesity has demonstrated that Liraglutide has significant results in weight loss. In SCALE trial, participants treated with Liraglutide 3mg, on average, they will lost 8 kg (17.6 lbs) over 56 weeks, compared to 2.8 kg (6.2 lbs) in the placebo group. In real-world settings, when coupled with lifestyle, patients get sustained weight loss.

③To protect Cardiovascular

In LEADER trial, Patients treat with Liraglutide peptide had a 13% reduction in MACE. Liraglutide helped participates reduce the risk of death from cardiovascular causes by 22%. Lower MACE risk means fewer type 2 diabetes patients experienced heart attacks, strokes, or cardiovascular deaths. This trial prove that Liraglutide not only a diabetes drugs but also cardioprotective agent.

Liraglutide dosage

AASraw’s Liraglutide comes in lyophilized powder form, before using it, you need to add sterile water to dissolve. AASraw as Liraglutide peptide supplier only, the dosage guide here are for information only.

The way of Liraglutide admistration is subcutaneous injection, you can inject it into your upper arm, abdomen or thigh. To get the best result fromLiraglutide, it is better to inject it at the same time each day in same or different site.

For type 2 diabetes dosage: Typically start with 0.6mg daily, after one week, increase the liraglutide dosage to 1.2mg. The dosage can be increased to 1.8 mg daily after another week, but no more than 1.8mg/day.

Liraglutide for weight loss dosage: The daily injection dosage is 0.6mg, increase the dose by 0.6mg each week until reach the maintenance dose 3mg daily. It is not suggest to dose over 3mg daily.

Liraglutide side effects

Liraglutide is effective weight loss medicine, it also has risks.

Common side effects are Vomiting, Diarrhea, Constipation, Indigestion or heartburn, Headache and Fatigue. These side effects are temporary, they will be gone after you stop taking Liraglutide.

The list below are Liraglutide Serious side effects, if you suffer them while you are taking Liraglutide, please call doctor for help. AASraw as peptide manufacturer only, we can’t provide very professional medical help.

Pancreatitis– Call your health provider right away if you feel severe pain from your adbomen to your back, and it will not go way.

Gallbladder problems– Stop taking Liraglutide if you have severe stomach pain, fever, yellowing of skin or eyes (jaundice) or clay-colored stools.

Kidney problems – If you have severe vomiting, nausea, or diarrhea, please go to see doctor at once. These will lead to dehydration.

Serious Allergic reactions – Some patients may allergic to Liraglutide, if you experience serious allergic reaction including difficulty breathing, very rapid heartbeat, severe rash or itching, please get medical help immediately.

Low Blood Sugar (Hypoglycemia) – Liraglutide increases insulin only when blood sugar is elevated. So its own will not cause hypoglycemia. This condition only comes if you combine Liraglutide with other diabetes medications. The symptoms of low blood sugar including confusion, sweating,  fast heartbeat, shakiness, blurred vision or blindness.

Liraglutide vs Semaglutide, which one is better?

Liraglutide and Semaglutide are both effective GLP-1 drugs to treat type 2 diabetes and promote weight loss, but they have difference in effectiveness, dosage frequency and results..etc.

①Effectiveness for blood sugar level control

When compare Liraglutide with Semaglutide, Liraglutide has weaker effectiveness on blood sugar control. Semaglutide leads to greater reduction in HbA1c reduction by around 1.8% to 2.0% from baseline, while Liraglutide typically reduces HbA1c by around 1.0% to 1.5% from baseline. If you are looking for stronger glucose control, semaglutide could be the more potent option.

②Weight loss

While Liraglutide still beneficial for weight loss, but it lose less compared to Semaglutide. Liraglutide can lose around 5-7% of their body weight over 56 weeks, while Semalgutide can loss 10-15% of the body weight. Semaglutide is more effective for weight loss.

③Dosage frequency

Both Liraglutide and semaglutide are administered via subcutaneous injection. Liraglutide require once-daily injections, while Semaglutide requires once-weekly injections. Semaglutide is more convenient for most of the people.

④Convenience

Semaglutide has oral tablet form to treat type 2 diabetes, while Liraglutide only have injection form.

⑤Cardiovascular Benefits

Liraglutide has more well-documented and longer time studies in cardiovascular benefits than semaglutide. This make Liraglutide more trusted by clinicians and patients with a history of heart disease

⑥Cost and Generic form

The cost of GLP-1 for weight loss expensive, especially for no insurance patients. Semaglutide tends to be more expensive than Liraglutide due to its stronger weight loss effect. Besides, Liraglutide generic form was already available in some markets, while Semagluitde generic form still need to wait few more years. This make Liraglutide cost cheaper than Semaglutide.

⑦Side effects

Both Liraglutide and Semaglutide cause nausea, vomiting, Constipation and other gastrointestinal issues. However, semaglutide tends to have a higher rate of gastrointestinal side effects, some people will suffer “Ozempic Face” due to its stronger effects.

⑧Availability

Liraglutide has been on the market longer than Semaglutide. And now Liraglutide generic was already available, so Liraglutide has less possible to shortage than semaglutide.

If you have adequate budget and look for greater weight loss and better blood sugar control, semagluitde maybe more appropriate. While Semalgutide have more potent benefits in weight loss and blood sugar level control, Liraglutide can be better fit for certain patients due to its daily dosing flexibility, well-documented cardiovascular protection and moderate weight loss.

Liraglutide peptide storage

The liraglutide comes from AASraw supplier is lyophilized powder form. The Lyophilized powder is easier to store than reconstituted liquid. It is better to store it in refrigerator at all times at temperature between 2°C and 8°C (36°F and 46°F), but do not freeze. After reconstituted, the solution should be stored at around 4 ℃, do not freeze it.

Can you switch from Liraglutide to Semaglutide for weight loss

With time go by, newer and stronger drug have been developed for type 2 diabetes and overweight. The most popular alternatives to Liraglutide are Semaglutide and Tirzepatide. Overall, they have betters effects than Liraglutide. If you want to switch from Liraglutide to Semagluitde or Tirzepatide, here is the tip for you:

  • When switching from Semaglutide to Liraglutide: Take 1st dose of Liraglutide seven days after last dose of Semaglutide. Gradually increase the Saxenda dose over the following weeks as your body adjusts.
  • When switching Liraglutide daily injecction to Semaglutide weekly injection: Take 1st dose of Semaglutide one day after last dose of Liraglutide.

Where to buy Liraglutide?

For those ready to take a significant step towards improving their weight management and overall health, online peptide suppliers AASraw offers the option to buy Liraglutide. Liraglutide is a weight loss medicine with a proven track record. Its effectiveness in glycemic control and weight managment make it a high demand drug in some countries. Due to Liraglutide high cost and the limitation of insurance coverage, it is difficult for some people to get Liraglutide. For those who want to buy affordable Liraglutide for weight loss, online peptide suppliers may be the alternative option. Ensure you buy Liraglutide from a reputable supplier which has good reviews, and test reports such as COA, hplc..etc. You can always buy Liraglutide wholesale from peptide manufacturer to get factory price.

Liraglutide Peptide Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? 
H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure.
For example,NMR can quantitatively analyze mixtures containing known compounds.For unknown compounds,NMR can
either be used to match against spectral libraries or to infer the basic structure directly.Once the basic
structure is known,NMR can be used to determine molecular conformation in solution as well as studying physical
properties at the molecular level such as conformational exchange,phase changes,solubility,and diffusion.

How to buy Liraglutide from AASraw?

❶To contact us by our email inquiry system,or leave your whatsapp number to us,our customer service representative(CSR) will contact with you in 12 hours.

❷To provide us your inquired quantity and address.

❸Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:

1.Ellen E

LadenheimDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

2.Prof Arne Astrup, MD

Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark

3.Mehta

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

4.Lotte Bjerre Knudsen

Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark

In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1] Ellegaard AM, Kårhus ML, Krych L, Sonne DP, Forman JL, Hansen SH, Dragsted LO, Nielsen DS, Knop FK. “Liraglutide and Colesevelam Changes Serum and Fecal Bile Acid Levels in a Randomized Trial with Patients with Bile Acid Diarrhea.“Clin Transl Gastroenterol. 2024 Sep 23. doi: 10.14309/ctg.0000000000000772. Online ahead of print.PMID: 39312459

[2] Apperley L, Parkinson J, Senniappan S. “Liraglutide Treatment Improves Glycaemic Dysregulation, Body Composition, Cardiometabolic Variables and Uncontrolled Eating Behaviour in Adolescents with Severe Obesity.” J Clin Res Pediatr Endocrinol. 2024 Sep 23. doi: 10.4274/jcrpe.galenos.2024.2023-10-10. Online ahead of print.PMID: 39311553

[3] Li X, Li Y, Lei C. “Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.” Int J Endocrinol. 2024 Sep 14;2024:1785321. doi: 10.1155/2024/1785321. eCollection 2024. PMID: 39309475

[4] Rossetti CL, Andrade IS, Fonte Boa LF, Neves MB, Fassarella LB, Bertasso IM, Souza MDGC, Bouskela E, Lisboa PC, Takyia CM, Trevenzoli IH, Fortunato RS, Carvalho DP. “LIRAGLUTIDE PREVENTS BODY AND FAT MASS GAIN IN OVARIECTOMIZED WISTAR RATS.” Mol Cell Endocrinol. 2024 Sep 19:112374. doi: 10.1016/j.mce.2024.112374. Online ahead of print. PMID: 39306226

[5] Dasso ME, Centola CL, Galardo MN, Meroni SB, Riera MF. “Glucagon-like peptide-1 analog, liraglutide, regulates Sertoli cell energy metabolism.” J Endocrinol. 2024 Sep 1:JOE-24-0274. doi: 10.1530/JOE-24-0274. Online ahead of print. PMID: 39303739

[6] Ghusn W, Hurtado MD. “Glucagon-like Receptor-1 agonists for obesity: Weight loss outcomes, tolerability, side effects, and risks.” Obes Pillars. 2024 Aug 31;12:100127. doi: 10.1016/j.obpill.2024.100127. eCollection 2024 Dec. PMID: 39286601

[7] Iacobellis G, Goldberger JJ, Lamelas J, Martinez CA, Sterling CM, Bodenstab M, Frasca D. “Liraglutide effects on epicardial adipose tissue micro-RNAs and intra-operative glucose control.” Nutr Metab Cardiovasc Dis. 2024 Aug 30:S0939-4753(24)00329-6. doi: 10.1016/j.numecd.2024.08.019. Online ahead of print. PMID: 39277531

[8] Gasoyan H, Pfoh ER, Schulte R, Le P, Butsch WS, Rothberg MB. “One-Year Weight Reduction With Semaglutide or Liraglutide in Clinical Practice.” JAMA Netw Open. 2024 Sep 3;7(9):e2433326. doi: 10.1001/jamanetworkopen.2024.33326. PMID: 39269703

[9] Jordan G, Young S, Alemán JO. “Weight Loss Pharmacotherapy: Current and Future Therapies.” Gastrointest Endosc Clin N Am. 2024 Oct;34(4):591-608. doi: 10.1016/j.giec.2024.06.006. PMID: 39277293

[10] Shieh C, Thompson HJ, McLaughlin E, Chiang CW, Hussan H. “Advancements in Understanding and Preventing Obesity-Related Colon Cancer.” Cancer J. 2024 Sep-Oct 01;30(5):357-369. doi: 10.1097/PPO.0000000000000744. PMID: 39312456


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