Orlistat powder

Orlistat Powder Basic Characters

What is Orlistat Powder?

Orlistat powder is a drug used for the treatment of obesity or overweight patients. It was first developed by Roche and launched in the United States in 1999. It is the only over-the-counter weight loss drug approved by FDA, CFDA, and EMA in the world. It works by inhibiting pancreatic and gastric lipases, the enzymes responsible for breaking down dietary fats in the gastrointestinal tract. This causes undigested fat to be excreted in the feces, resulting in fewer calories absorbed from fat.

In the United States, orlistat is approved for the treatment of body mass index (BMI, Body Mass Index, unit kg/㎡) reaching or exceeding 30 (the US obesity standard). Besides, people with a body mass index between 27 and 30 and other health risk factors such as high blood pressure or diabetes.

How Does Orlistat Powder Work?

Orlistat powder works by inhibiting gastric and pancreatic lipases, which are enzymes responsible for breaking down triglycerides into smaller fatty acids that can be absorbed by the body. By inhibiting these enzymes, AASraw orlistat prevents the hydrolysis of triglycerides in the intestine, which leads to a decrease in the amount of absorbed dietary fat.

Since triglycerides are not broken down into free fatty acids, they are excreted unchanged in the feces. This process leads to a reduction in caloric intake and promotes weight loss. Orlistat has been shown to prevent approximately 30% of dietary fat from being absorbed.

In addition to inhibiting lipases, orlistat also inhibits the thioesterase domain of fatty acid synthase (FAS). This enzyme is involved in the proliferation of cancer cells but not normal cells. However, potential side effects of orlistat, such as inhibition of other cellular off-targets or poor bioavailability, might hamper its application as an effective antitumor agent.

Overall, orlistat’s mechanism of action involves the inhibition of enzymes involved in fat digestion, leading to a reduction in the amount of absorbed dietary fat and promoting weight loss.

Benefits of Using Orlistat Powder

Orlistat powder is a medication mainly used to treat obesity, primarily by preventing the absorption of fats from the human diet. Additionally, it can modestly reduce blood pressure and appears to prevent the onset of type 2 diabetes, whether from the weight loss itself or other effects.

· Treatment of Obesity

Orlistat powder is primarily used for the treatment of obesity in conjunction with a healthcare provider-supervised reduced-calorie diet. Its primary function is to prevent the absorption of dietary fats by acting as a lipase inhibitor, thereby reducing caloric intake.AASraw Orlistat powder works by inhibiting gastric and pancreatic lipases, the enzymes responsible for breaking down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids and instead are excreted unchanged.

Pooled data from clinical trials suggests that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4–7 lb) more than those not taking the drug over the course of a year. Between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body fat. It is worth noting that after orlistat was stopped, a significant number of subjects regained weight—up to 35% of the weight they had lost.

· Reduction of Blood Pressure

In addition to aiding in weight loss, studies have shown that orlistat powder can also lead to a modest reduction in blood pressure. Pooled data from clinical trials suggests that orlistat reduces systolic and diastolic blood pressure by an average of 2.5 and 1.9 mmHg, respectively. The mechanism behind this reduction in blood pressure is thought to be related to the weight loss achieved through orlistat use, as obesity is a known risk factor for hypertension. However, it is important to note that the reduction in blood pressure achieved through orlistat use is relatively small and should not be relied upon as the sole treatment for hypertension. People with hypertension should continue to follow the advice of their healthcare provider and use medication as prescribed.

· Prevention of Onset of Type 2 Diabetes

Orlistat powder has been shown to have a preventive effect on the onset of type 2 diabetes, besides its weight loss and blood pressure-lowering effects. This is likely due to the fact that obesity is a major risk factor for developing type 2 diabetes, and Orlistat can help with weight loss in obese individuals. Studies have shown that orlistat can reduce the incidence of type 2 diabetes in people who are obese by around the same amount that lifestyle changes do. The exact mechanism by which orlistat prevents the onset of type 2 diabetes is not well understood, but it is thought to be related to the drug’s ability to reduce caloric intake by inhibiting the absorption of dietary fat, which may lead to improved glucose metabolism and insulin sensitivity. It is important to note that orlistat is not a substitute for a healthy lifestyle, and its use should always be combined with a reduced-calorie diet and exercise for maximum effectiveness.

Notes: To maximize the advantages of Orlistat powder, it is critical to purchase it from a trusted provider.AASraw supplies high-quality Orlistat powder at reasonable prices, as a professional Orlistat powder supplier with an independent R&D center and factory. When you buy Orlistat powder from AASraw, you can be confident that you are obtaining a pure, high-quality product that adheres to stringent quality requirements.

The Side Effects of Orlistat Powder?

Orlistat powder, like any medication, has potential side effects. Although it only affects the gastrointestinal tract and not the cardiovascular or central nervous systems, the side effects cannot be ignored.

Common side effects

Oily stools or oily spotty stools

• Flatulence
• Abdominal discomfort
• Stool urgency
• Increased stool frequency
• Fecal incontinence
• Oily spotting
• Increased gastrointestinal flatus
• Fatty (oily) stools
• Steatorrhea

As the fat content in the diet increases, the incidence rate also increases accordingly. Most patients can improve after taking medication for a period of time.

Acute gastrointestinal reactions

• Abdominal pain/discomfort
• Watery stools
• Soft stools
• Rectal pain/discomfort,
• Dental discomfort
• Gum discomfort

Notes: It is worth noting that the quality of orlistat powder is closely related to side effects, and high-quality orlistat powder can reduce the risk of side effects. Buying from a reputable raw powder supplier like AASraw can help reduce the risk of side effects effectively.AASraw supplies high-quality Orlistat powder manufactured under strict GMP standards ensuring purity and potency. However, it is important to always consult a healthcare professional before starting any new medication or supplement regimen.

Dosage and Administration of Orlistat Powder for Reference

Orlistat powder is a prescription medication used for the management of weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. The recommended dosage and administration of Orlistat powder are as follows.

Dosage

The recommended dose of Orlistat powder is 120 mg taken orally 3 times a day with each main meal that contains fat. The total daily dose should not exceed 360 mg.

Administration

Orlistat powder should be taken orally during, or up to one hour after, each main meal that contains fat. If a meal is missed or contains no fat, the dose of Orlistat powder may be skipped. Patients should be advised to take a multivitamin containing fat-soluble vitamins at least two hours before or after taking Orlistat powder.

Dosage Adjustment

No dose adjustment is necessary for patients with renal or liver impairment. However, patients with diabetes mellitus may require dose adjustment of their diabetes medications, and glycemic control should be closely monitored.

Precautions

It is important to note that Orlistat powder should not be used during pregnancy or by those with chronic malabsorption syndrome, cholestasis, or hypersensitivity to the active substance or any product excipients. Patients with diabetes mellitus may need to adjust their diabetes medications and monitor glycemic control closely.

Notes

The dosage and administration information provided about Orlistat powder is for informational purposes only and should not be used as a substitute for professional medical advice. Always consult with a healthcare provider before starting any medication or supplement, including Orlistat powder. The dosage and administration of Orlistat powder should be determined based on individual medical history, current medications, and other relevant factors. Moreover, buying Orlistat powder with high quality from a reliable Orlistat powder supplier or wholesaler is quite important.

Orlistat Interactions with Other Medications

• Orlistat can reduce the absorption of vitamins A, D, and E. Therefore, if you are taking preparations containing vitamins A, D, and E (such as some multivitamin preparations), you should take vitamins 2 hours after taking orlistat.
• Patients with type 2 diabetes may need to reduce the dose of oral hypoglycemic agents (such as sulfonylureas).
• Co-administration of orlistat with cyclosporine may cause a decrease in the plasma concentration of the latter.
• When orlistat is used in combination with amiodarone, it may reduce the absorption of the latter and reduce the curative effect.
• If it is used with other drugs at the same time, drug interactions may occur, please consult your physician or pharmacist for details.

Where to buy Orlistat Powder?

Finding a reliable and reputable Orlistat powder supplier is crucial for those in the pharmaceutical or healthcare industry who need this medication for their products or patients. It is important to choose a supplier that can provide high-quality Orlistat powder that meets the required standards and regulations. The supplier should also have a good track record in terms of quality control, packaging, shipping, and customer service. By selecting a reliable supplier, customers can ensure that they receive a safe and effective product for their needs.

AASraw is a well-established supplier of pharmaceutical raw materials, including Orlistat powder. They have a strict quality control system in place to ensure that their products are of high quality and meet the required standards. They also provide customers with a certificate of analysis for each batch of Orlistat powder they sell, so you can be assured of the purity and quality of the product. In addition, AASraw offers competitive pricing and reliable delivery, which are important factors to consider when choosing a supplier. Overall, AASraw is a reputable supplier of Orlistat powder that offers high-quality products, competitive pricing, and reliable delivery.

Orlistat Powder Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? 
H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure. For 
example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR 
can(either be used to match against spectral libraries or to infer the basic structure directly. Once the
basic structure is known, NMR can be used to determine molecular conformation in solution as well as 
studying physical properties at the molecular level such as conformational exchange, phase changes,
solubility, and diffusion.

Orlistat powder(96829-58-2)-COA

Orlistat powder(96829-58-2)-COA

How to buy Orlistat Powder from AASraw?

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Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Xiongcai Feng
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
2. Jovana V. Jovankić
University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000, Kragujevac, Serbia
3. Sandhya R. Bassin MD
Icahn School of Medicine at Mount Sinai, Department of Endocrine, Diabetes, and Bone Disease
4. Vian Ahmed Wasta Esmail
Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1] Siebenhofer A,Winterholer S,Jeitler K,Horvath K,Berghold A,Krenn C,Semlitsch T (January 2021). “Long-term effects of weight-reducing drugs in people with hypertension”. The Cochrane Database of Systematic Reviews. 1 (1):CD007654.

[2] Mancini MC,Halpern A (April 2006). “Pharmacological treatment of obesity”. Arquivos Brasileiros de Endocrinologia e Metabologia. 50 (2):377–389.

[3] Heck AM,Yanovski JA,Calis KA (March 2000). “Orlistat,a new lipase inhibitor for the management of obesity”. Pharmacotherapy. 20 (3):270–279.

[4] Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,et al.(August 2006).”The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen”. Cancer Letters. 240 (2):221–224.

[5] “FDA Approves Orlistat for Over-the-Counter Use” (Press release).U.S.Food and Drug Administration (FDA).7 February 2007.Archived from the original on 13 May 2009.Retrieved 7 February 2007.

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