Product Description
What is Semax?
Semax is a new neuroprotective peptide, which is derived from the molecular structure of adrenocorticotropic hormone (ACTH), is a natural substance found in the human body, also known as MEHFPGP. It was developed by a Russian research team from the Institute of Molecular Genetics, initially, it was pursued as a treatment for stroke victims suffering brain damage. However, Semax also has similar history, potency, and chemical makeup to Noopept powder. In Russia and Ukraine, Semax is approved to use to prevent and treat circulatory disorders, it often is marketed as a “nootropic” or a “smart drug” and is believed to improve cognitive function and memory. However, in the U.S.A, Semax serves as a base component for a number of pharmacological products, that use to treat in clinical practice for the treatment of CNS diseases (ischemic brain stroke,dys-circulatory encephalopathy, optic nerve atrophy, etc).
Semax is typically administered as a nasal spray or subcutaneous injection and has poor oral bioavailability. Its usage and dosage regimen varies depending on the specific condition for treatment. If you are considering buying a peptide of Semax powder or finished vials online, a reputable supplier is an especially important option, that can ensure you get the quality of peptide Semax. And, AASraw can supply high-quality peptides with the support of the independent R&D center and factory, Semax wholesale orders are acceptable.[1][2]
How does Semax work
Semax works through multiple mechanisms to promote various aspects of brain function and health, following are some of the proposed ways that Semax may exert its effects:
(1)Neurotrophic factor modulation
Semax enhances the levels and activity of brain-derived neurotrophic factor (BDNF) and can promote the growth, development, and survival of neurons, to help to learn and improve memory.
(2)Dopaminergic system modulation
Semax affects the dopamine system in the brain, can promote to release of dopamine, and enhances dopamine receptor sensitivity, leading to improve cognitive functions and mood regulation.
(3)Anti-inflammatory and antioxidant effects
Semax exhibits anti-inflammatory properties by reducing the production of pro-inflammatory molecules and promoting the release of anti-inflammatory substances. It also acts as an antioxidant, protecting neurons from oxidative stress and damage caused by free radicals.[6][3]
(4)Neuropeptide modulation
Semax can influence the levels and activity of various neuropeptides, it may contribute to pain relief, anti-inflammatory effects, and immune system modulation by regulating these neuropeptides.
(5)Neuroprotective effects
Semax has shown neuroprotective properties by enhancing neuronal survival, reducing neuronal apoptosis (cell death), and promoting neuronal recovery and regeneration. It helps protect neurons from damage and supports their overall health and function.
(6)Cognitive enhancement
Semax can enhance synaptic plasticity, help to strengthen or weaken in response to neural activity and lead to improving cognitive performance.
It’s important to note that Semax research is still ongoing, there are many of its exact mechanisms and effects are not yet fully understood.[1][6] But, in the current market, Semax is mainly sold as a “cognitive enhancer” and “neuroprotective agent”, which is one of the best nootropics supplements.[7]
The potential benefits when you using Semax
Semax is a nootropic drug that has been shown to offer many potential benefits and uses in various areas, following is researcher reported benefits:
①Improve attention and memory: Some users have reported improvements in attention span and memory abilities while using Semax.
②Reduced anxiety and depression symptoms: Semax has been reported to have mood-regulating effects, potentially reducing symptoms of anxiety and depression.
③Improved mental clarity and focus: Users have described an increase in mental clarity and focus with Semax use.
④Reduced effects from stress: Semax may have the ability to mitigate the negative effects of stress on the body and promote a sense of calmness.
For Medical Conditions when Semax use for treatment
①Anxiety disorder: Semax has been prescribed for the treatment of anxiety disorders, although more research is needed to establish its efficacy.
②Ischemic events and stroke: Semax has been investigated for its potential to aid in stroke recovery and reduce damage caused by ischemic events.
③Nerve regeneration: Semax has shown potential in promoting nerve regeneration and repair.
④ADHD: Semax has been used as an alternative treatment for ADHD, although its effectiveness in this regard requires further investigation.
⑤Opioid withdrawal: Semax has been explored as a potential aid in managing withdrawal symptoms during opioid addiction treatment.
⑥Chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s: Semax has been studied in preclinical models and shows promise in potentially improving symptoms and disease progression in these conditions, but further research is needed.
⑦Thrombosis: Semax has been investigated for its potential in preventing and treating thrombosis, although more research is necessary to establish its effectiveness.
⑧Gastric issues: Semax has been explored for its potential in the treatment of gastric-related disorders, but clinical evidence is limited.
What is the side effect of Semax?
As some research and user reports, Semax is generally considered to be safe and well-tolerated. However, like any substance, Semax may have potential side effects. It’s important to note that individual responses to Semax can vary, and not everyone may experience these side effects. Here are some potential side effects associated with Semax:
▪ Hair loss
▪ Nausea
▪ Vomiting
▪ Headaches
▪ Mild fatigue
▪ Restlessness
▪ Nasal irritation
▪ Allergic reactions
▪ Sleep disturbances
▪ Changes in appetite
▪ Increase in blood sugar levels
It’s worth noting that Semax has been extensively studied in Russia and used in clinical practice for several years, with a relatively good safety profile. But, if you’re a new user with Semax, usually not advise work Semax stack with other nootropics or supplements, that might increase the risk of adverse side effects. If you insist to do this thing, you’d better consult with a healthcare professional before using it.
Semax VS Selank: Similarities and Differences
Semax and Selank are both peptide drugs with potential cognitive and mood-enhancing effects, but they have different mechanisms of action and applications. Here’s a comparison between Semax and Selank:
(1)Mechanism of Action:
Semax: Semax is derived from a peptide called adrenocorticotropic hormone (ACTH). It works by modulating the levels of neurotransmitters such as dopamine, serotonin, and norepinephrine in the brain. Semax primarily acts as a neuroprotective and cognitive-enhancing agent.
Selank: Selank is a synthetic peptide that is based on a fragment of the peptide Tuftsin. It acts as an anxiolytic and antidepressant by regulating the levels of stress-related hormones, such as cortisol. Selank also affects the levels of neurotransmitters, including serotonin.
(2)Effects and Benefits
Semax: Semax is known for its potential benefits in improving cognitive functions such as attention, memory, and focus. It may also help reduce symptoms of anxiety, depression, and stress. Semax has been studied in conditions such as stroke, ADHD, and neurodegenerative diseases.
Selank: Selank is primarily used for its anxiolytic and antidepressant effects. It may help reduce anxiety symptoms, promote relaxation, and improve mood. Selank has been studied in anxiety disorders, depression, and post-traumatic stress disorder (PTSD).
(3)Administration
Semax: Semax is commonly available as a nasal spray and is administered intranasally.
Selank: Selank is also available as a nasal spray, but it can also be injected subcutaneously.
(4)Safety Profile
Semax: Semax is generally considered to be safe and well-tolerated, with few reported side effects. Commonly reported side effects include mild nasal discomfort, headaches, and transient irritation.
Selank: Selank is also considered to have a good safety profile, with few reported side effects. Some users may experience mild nasal discomfort or headaches.
It’s important to note that the effects and benefits of both Semax and Selank are still being studied, and the available evidence is limited. The effectiveness and appropriate usage of these peptides may vary among individuals. It’s advisable to consult with a healthcare professional before considering the use of Semax, Selank, or any other peptide-based medication, as they can provide personalized advice based on your specific needs and medical history.
Where to buy Semax online?
It is indeed crucial to be cautious when you want to purchase Semax or any other nootropic supplement online, as counterfeit products can be a concern. To ensure you are purchasing high-quality Semax that is both safe and potent, it is best to purchase directly from a reputable Semax factory, authorized Semax reseller, or Semax company with reliable customer reviews. Before ordering Semax, you should do more research about Semax vendors, manufacturing processes, and quality control measures.
We highly recommend AASraw, which is a reputable and professional manufacturer and supplier that specializes in providing a wide range of peptide raw powders and vials. With our expertise and experience in the industry, we offer high-quality products to meet the needs of researchers, pharmaceutical companies, and individuals involved in peptide synthesis and development. If you want to find a reliable Semax supplier, AASraw is a great option.[3][4]
Semax Testing Report-HNMR
What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly.[1][6] Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.
How to buy Semax from AASraw?
❶To contact us by our email inquiry system, or leave your WhatsApp number to us, our customer service representative(CSR) will contact you in 12 hours.
❷To provide us with your inquired quantity and address.
❸Our CSR will provide you with the quotation, payment term, tracking number, delivery ways, and estimated arrival date(ETA).
❹Payment done and the goods will be sent out in 12 hours.
❺Goods received and give comments.
Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine
Scientific Journal paper Author:
1.Nataliya Yu.Glazova
Institute of Molecular Genetics,RAS,2 Akademika Kurchatova square,Moscow 123182,Russia
2.D.Khukhareva
Lomonosov Moscow State University,Biological- Human and Animal phisiology,Moscow,Russian Federation
3. Antonio Magrì
Istituto di Biostrutture e Bioimmagini,Consiglio Nazionale delle Ricerche (CNR),Via P.Gaifami 18,95126 Catania,Italy
4.T.Y.Agapova
The Laboratory of Molecular Genetics of Hereditary Diseases,Department of Molecular Basis of Human Genetics,Institute of Molecular Genetics RAS,2 Kurchatov Sq.,Moscow 123182,Russia
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.
Reference
[1] Sciacca MFM,Naletova I,Giuffrida ML,Attanasio F.”Semax,a Synthetic Regulatory Peptide,Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.” ACS Chem Neurosci.2022 Feb 16;13(4):486-496.PMID: 35080861.
[2] Sudarkina OY,Filippenkov IB”Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion”.Int J Mol Sci.2021 Jun 8;22(12):6179.PMID: 34201112
[3] Dergunova LV,Dmitrieva VG”The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain”.Mol Biol (Mosk).2021 May-Jun;55(3):402-411.PMID: 34097675.
[4] Panikratova YR,Lebedeva IS”Functional Connectomic Approach to Studying Selank and Semax Effects”.Dokl Biol Sci.2020 Jan;490(1):9-11.PMID: 32342318.
[5] Slominsky PA,Shadrina MI”Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.Dokl Biol Sci.2017 May;474(1):106-109.PMID: 28702721.
[6] Kaplan AY,Kochetova AG,Nezavibathko VN,Rjasina TV,Ashmarin IP (September 1996).”Synthetic acth analogue semax displays nootropic‐like activity in humans”.Neuroscience Research Communications.19 (2): 115–123.doi:10.1002.
[7] Tabbì G,Magrì A”Semax,an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity”J Inorg Biochem.2015 Jan;142:39-46.doi: 10.1016.PMID: 25310602.
