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The 7 Best Nootropics(Smart Drugs) in the market of Noopept


The memory-improving drug “Noopept” was created in 1992 by a research group at the Scientific Research Institute of Pharmacology. VV Zakusov And this drug was acknowledged not only in Russia, but also in the United States, where it was patented three years after it was registered in Russia. The transfer of trademark rights and a number of business reorganizations had no effect on the drug’s popularity. Noopept’s sales were expected to be $ 6.2 million per year twenty years after its invention.


1.Noopept drug
2.Noopept Pharmacokinetics
3.Noopept powder Indications
4.Mode of application
5.Noopept Side effects and contraindications
6.The response of “nootropian” about the action of “Noopept” and natural analogues
7.Noopept powder Contraindications
8.Noopept powder Overdose
9.Noopept powder Side effects
10.Noopept powder Terms and conditions of storage

Noopept drug

The drug “Noopept“, used to improve memory, was developed in 1992 by a research group of the Scientific Research Institute of Pharmacology. Zakusov VV And this drug was recognized not only in Russia, but also in the US, where it was patented after three years, after registration at home. The transfer of trademark rights and a number of commercial reorganizations did not affect the popularity of the drug. Twenty years after the invention of Noopept, its sales were estimated at $ 6.2 million per year.

“Noopept” differs from other nootropic drugs, also included in this group, in that it simultaneously affects all stages of the memory process:

• initial processing of incoming information,
• long-term storage of material,
• timely retrieval of information.

Consideration of the mechanism of action of nootropic drugs in general and “Noopept” in particular will help correct comparison of the drug
with other representatives of the nootropic group.

Noopept Pharmacokinetics

10 mg of N-phenylacetyl-L-prolylglycine ethyl ester are absorbed into the systemic blood stream unchanged in the intestinal tract and then, overcoming the blood-brain barrier, enter the brain, where, after 15 minutes, they are detected at greater thanblood, and concentrations. Half-life from the blood plasma occurs in 0.38 hours. The substance is partially metabolized, during which phenylacetic acid, cycloprolylglycine and phenylacetylproline are formed. Bioavailability is determined at the level of 99.7%.

Noopept powder Indications

Noopept is used in the therapy of attention breakdown, memory loss, as well as other cognitive functions or emotionally labile disorders that have emerged against the backdrop of postcommunity syndrome, asthenic disorders, cerebral vascular insufficiency, brain trauma and pathological conditions that reduce intellectual potential.

Mode of application

The pill “Noopept” is taken after a meal. At the initial dose of 20 mg divided into two doses (morning and evening), with insufficient effectiveness and good tolerability, you can go to 30 mg (three times a day for 10 mg), counting so that the last reception was not later than 18 hours. One course lasts from 1.5 to 3 months, and a second course can be carried out with a one-month break.

Noopept Side effects and contraindications

Almost all nootropics powder mean a ban on the use of women during pregnancy. However, with the reception of “Noopept” in the list of contraindications is included:

• restriction on age to 18 years,
• deficiency of lactase,
• marked violations in the liver and kidneys,
• lucose-galactose malabsorption,
• lactose intolerance.

The last factor associated with a pathological reaction to lactose (milk) among the eastern Slavs is observed in 16-18% of the population. For Europe, this is the average figure – more for Austrians (up to 20%), Finns (18%), Italians (depending on the region from 15 to 52%), Balkans and residents of Crete (56%). In the south of France, this figure reaches 67%, and in Sicily – 71%. The percentage of lactose intolerance among the inhabitants of Central Asia is 80 – this means that 4 out of 5 people cannot use this nootropic drug. In this case, it is more expedient to switch to alternative natural remedies with a similar nootropic effect (for example, ” HeadBooster “), but as well as the reception of “Noopept”, it is necessary to take into account hypersensitivity to the components.
Side effects of “Noopept” include allergic reactions and the possibility of lifting blood pressure in people with arterial hypertension.

The response of “nootropian” about the action of “Noopept” and natural analogues

People who use nootropic drugs for medical purposes, but to expand memory and stimulate brain activity (“nootropics“), usually experience the effect of various substances and can make a comparative subjective assessment.

So, “Noopept” is described as a drug, which already in the second week of reception allows you to keep increased intellectual activity throughout the day. It is noted that there are no headaches that usually occur with the same load, if the drug is not taken for a long time. Separate mention of dreams, which when receiving this nootropy become more vivid and expressive.

Similar characteristics for a subjective description are, for example, Semax, Optimentis (Optimumis), HeadBooster (HeadBuster), etc., but not all preparations are described in the same way. For example, “Fenibut”, which is also used to strengthen memory and attention, reducing nervousness, simultaneously makes a person quite emotionless with slightly slower reactions.

Noopept powder Contraindications

Noopept is not assigned to patients with severe renal dysfunction, liver dysfunction, lactose deficiency, glucose-galactose malabsorption or lactose intolerance. In addition, it is necessary to refrain from prescribing the drug to pregnant, lactating, as well as patients who are under 18 and patients with individual hypersensitivity components of the drug.

Application in pregnancy and lactation

The prescription of the drug Hoenopt for breastfeeding and pregnant women is highly undesirable, since there is no reliable information about the peculiarities of the influence of noopept on the development of a fetus or a newborn who is breastfed in women receiving treatment with the drug.

The 7 Best Nootropics(Smart Drugs) in the market of Noopept

Dosing and Administration

Hopepe is used for oral administration. Tablets should be taken after meals and drink plenty of liquid. In connection with the fact that the drug has an exciting effect, it must be taken no later than 18:00. Duration of treatment and the dose of the medicine the doctor calculates independently.

At the beginning of treatment, the patient is recommended to take 10 mg of the drug 2 times a day. If, when taking the drug in minimal doses, it was not possible to achieve the necessary therapeutic effect, the frequency of reception is increased to three times a day.

The drug is intended for long-term use, the course of treatment can vary from 1.5 to 3 months. It is possible to conduct repeated courses of treatment thirty days after the last drug intake.

If pain is needed to take Noopept in high doses for a long time, then the patient must be under constant medical observation.

Noopept powder Overdose

Even with the reception of Noopept in high doses, patients do not develop symptoms of acute poisoning. Despite the non-toxicity of the drug, if you notice that the patient accidentally took the drug in a higher dosage, then he should rinse the stomach and ensure the production of activated carbon and abundant drinking.

Noopept powder Side effects

Noopept is well tolerated. During treatment, patients develop hypertension and various allergic reactions.

If, when using Noopept, the patient has uncharacteristic symptoms for the medicine, they should be immediately notified to the treating doctor who will decide on the advisability of further treatment.

Noopept powder Terms and conditions of storage

Noopept must be stored in a dry, protected from light place, which is not accessible to children. The duration of storage of the preparation Hoenopt is 3 years.


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Author of this article:

Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:

1.Rodion V. Kondratenko

Brain Science Institute, Research Center of Neurology, 105064 Moscow, Russia

2.Perihan Gürbüz

Inonu University, Faculty of Medicine, Department of Physiology, Malatya, Turkey

3.Praveen K. Srivastava

Shri G.H. Patel Pharmacy Building, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara 390 002, Gujarat, India

4.Xueen Jia

Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden

5.Rodion V. Kondratenko

Department of Brain Research, Scientific Center of Neurology, Russian Academy of Medical Sciences, by-str. Obukha 5, Moscow 105064, Russia

6.L F Zainullina

Zakusov Research Institute of Pharmacology, Moscow, Russia.

7.Rita U Ostrovskaya

Zakusov Institute of Pharmacology RAS, Baltiyskaya 8, 125315, Moscow, Russia.

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1] Rodion V. Kondratenko, Igor S. Povarov, Sergey N. Kolbaev, Vladimir I. Derevyagin, Rita U. Ostrovskaya, Tatyana A. Gudasheva, Irina N. Sharonova, Vladimir G. Skrebitsky.”Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from  rat.”https://doi.org/10.1016/j.neulet.2022.136898

[2] Perihan Gürbüz, Halil Düzova, Azibe Yildiz, Pınar Çakan, Gül Büşra Kaya, Harika Gözde Gözükara Bağ, Merve Durhan, Cemile Ceren Gül, Aslı Çetin Taşlidere.”Effects of noopept on cognitive functions and pubertal process in rats with diabetes.”https://doi.org/10.1016/j.lfs.2019.116698

[3] Praveen K. Srivastava, Hetal P. Thakkar. “QbD-driven development of dissolving microneedle patch loaded with ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage dementia.”https://doi.org/10.1016/j.ejps.2021.105909

[4] Xueen Jia, Anna L. Gharibyan, Anders Öhman, Yonggang Liu, Anders Olofsson, Ludmilla A. Morozova-Roche.”Neuroprotective and Nootropic Drug Noopept Rescues α-Synuclein Amyloid Cytotoxicity.”https://doi.org/10.1016/j.jmb.2011.09.044

[5] Author links open overlay panelRodion V. Kondratenko, Vladimir I. Derevyagin, Vladimir G. Skrebitsky.”Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells.”https://doi.org/10.1016/j.neulet.2010.04.005

[6] Zainullina LF, Ivanova TV, Sadovnikov SV, Vakhitova YV, Seredenin SB.”Cognitive Enhancer Noopept Activates Transcription Factor HIF-1.”Dokl Biochem Biophys. 2020 Sep;494(1):256-260. doi: 10.1134/S1607672920050129. Epub 2020 Oct 20.PMID: 33119829

[7] Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, Mohammadi M, Danyali S, Ghasemi R, Zaringhalam J. “Retraction notice to “Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process” [Heliyon (2021) e06219].”Heliyon. 2021 May 17;7(5):e06981. doi: 10.1016/j.heliyon.2021.e06981. eCollection 2021 May.PMID: 34041381

[8] Düzova H, Nazıroğlu M, Çiğ B, Gürbüz P, Akatlı AN.”Noopept Attenuates Diabetes-Mediated Neuropathic Pain and Oxidative Hippocampal Neurotoxicity via Inhibition of TRPV1 Channel in Rats.”Mol Neurobiol. 2021 Oct;58(10):5031-5051. doi: 10.1007/s12035-021-02478-8. Epub 2021 Jul 9.PMID: 34241806

[9] Ostrovskaya RU, Zolotov NN, Ozerova IV, Ivanova EA, Kapitsa IG, Taraban KV, Michunskaya AM, Voronina TA, Gudasheva TA, Seredenin SB.”Noopept normalizes parameters of the incretin system in rats with experimental diabetes.”Bull Exp Biol Med. 2014 Jul;157(3):344-9. doi: 10.1007/s10517-014-2562-5.PMID: 25065315

[10] Ostrovskaia RU, Gudasheva TA, Voronina TA, Seredenin SB.”[The original novel nootropic and neuroprotective agent noopept].”Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72.PMID: 12596521

[11] Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, Mohammadi M, Danyali S, Ghasemi R, Zaringhalam J.”Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process.”Heliyon. 2021 Feb 12;7(2):e06219. doi: 10.1016/j.heliyon.2021.e06219. eCollection 2021 Feb.PMID: 33644478

[12] Zainullina LF, Ivanova TV, Ostrovskaya RU, Gudasheva TA, Vakhitova YV, Seredenin SB.”Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation.”Bull Exp Biol Med. 2019 Feb;166(4):466-468. doi: 10.1007/s10517-019-04373-8. Epub 2019 Feb 20.PMID: 30788746

[13] Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB.”Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bull Exp Biol Med. 2008 Sep;146(3):334-7. doi: 10.1007/s10517-008-0297-x.PMID: 19240853

[14] Gurbuz P, Duzova H, Taslidere AC, Gul CC.”Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats.”Biotech Histochem. 2023 Nov;98(5):314-325. doi: 10.1080/10520295.2023.2187460. Epub 2023 Mar 22.PMID: 36946173

[15] Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB.”Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.”J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2.PMID: 25096780

[16] Ostrovskaya RU, Yagubova SS, Zhanataev AK, Anisina EA, Gudasheva TA, Durnev AD.”Neuroprotective Dipeptide Noopept Prevents DNA Damage in Mice with Modeled Prediabetes.”Bull Exp Biol Med. 2019 Dec;168(2):233-237. doi: 10.1007/s10517-019-04681-z. Epub 2019 Nov 27.PMID: 31776952

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