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Urolithin A powder

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Other names:Uro-A

Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Noted: Urolithin A 8-Methyl Ether(CAS:35233-17-1) is an intermediate in the synthesis of Urolithin A, a major metabolite of Ellagitannin and exhibits anti-inflammatory and antioxidant properties.

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Product Description

Basic Characteristics

Product NameUrolithin A
CAS Number1143-70-0
Molecular FormulaC13H8O4
Formula Weight228.2
Synonyms2′,7-Dihydroxy-3,4-benzocoumarin

3,8-Dihydroxy Urolithin;

Urolithin A 8-Methyl Ether;

3-Hydroxy-8-methoxy-6H-dibenzo[b,d]pyran-6-one.

AppearanceWhite crystalline powder
Storage and HandlingDry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Raw Urolithin A powder Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? 
H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure. For 
example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR 
can(either be used to match against spectral libraries or to infer the basic structure directly. Once the
basic structure is known, NMR can be used to determine molecular conformation in solution as well as 
studying physical properties at the molecular level such as conformational exchange, phase changes,
solubility, and diffusion.

Urolithin A powder(1143-70-0)-COA

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Anurag Singh
Amazentis SA, EPFL Innovation Park, Bâtiment C, 1015 Lausanne, Switzerland
2. Hidehiko Kikuchi
Department of Food and Nutrition, Shokei University Junior College, 2-6-78 Kuhonji, Chuo-ku, Kumamoto, 862-8678, Japan
3. Dominic Denk
Department of Medicine 1, Goethe-University Hospital Frankfurt, Frankfurt/Main, Germany
4. Davide D’Amico
Amazentis SA, EPFL Innovation Park, Bâtiment C, CH-1015 Lausanne, Switzerland
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

Reference

[1] Spendiff, S. et al. Mitochondrial DNA deletions in muscle satellite cells: implications for therapies. Hum. Mol. Genet. 22, 4739–4747 (2013)

[2] Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 November 2009). “Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay”. J Agric Food Chem. 57 (21): 10181–6. doi:10.1021/jf9025794. PMID 19824638.

[3] Milburn, M. V. & Lawton, K. A. Application of metabolomics to diagnosis of insulin resistance. Annu. Rev. Med. 64, 291–305 (2013).

[4] Cerdá, Begoña; Tomás-Barberán, Francisco A.; Espín, Juan Carlos (2005). “Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability”. Journal of Agricultural and Food Chemistry. 53 (2): 227–235. doi:10.1021/jf049144d. PMID 15656654.

[5] Laker, R. C. et al. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat. Commun. 8, 548 (2017).


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