Product Description
Basic Characters
| Name: | SLU-PP-332 |
| CAS: | 303760-60-3 |
| Molecular Formula: | C18H14N2O2 |
| Molecular Weight: | 290.32 |
| Color: | White to off-white |
| Storage temp: | 2-8°C |
What Is SLU-PP-332?
SLU-PP-332 is an agonist for estrogen-related receptor (ERR) α, β, and γ nuclear receptors, with the strongest effect on ERRα. The EC50 values of SLU-PP-332 for ERRα, ERRβ, and ERRγ are 98, 230, and 430 nM, respectively. SLU-PP-332 belongs to exercise mimetics and gains increasing attention for its potential in fat burning and metabolic regulation.
Why Was SLU-PP-332 Developed?
As the weight loss drugs like GLP-1 receptor agonists (semaglutide, tirzepatide, retatrutide…) are gaining more and more popularity, people are increasingly turning to medication to manage their weight. As we know that GLP-1 receptor agonists have shown great efficacy on weight loss, however, some experts stress that they will also decrease muscle mass. Obviously, there is a demand for a medication which can burn fat meanwhile maintain muscle. Therefore, SLU-PP-332 was developed.
What Are the Results of SLU-PP-332?
A new research on SLU-PP-332 was published in The Journal of Pharmacology and Experimental Therapy in September 2023. It demonstrated that mice seemed to have run on a treadmill for several hours after took SLU-PP-332, and the following changes were observed:
- Increased fatty acid oxidation, and the body turned to burning fat (similar to the body using fatty acids when fasting or exercising).
- Enhanced mitochondrial respiration, and enhanced skeletal muscle oxidation capacity and endurance, increased mitochondrial content, and changes similar to those that occurred in aerobic training.
- Reduced glycogen and increased pyruvate in muscles.
- Increased resting energy expenditure.
- Mice with normal weight extended running time by 70% and running distance by 45%.
- Mice with normal weight increased energy consumption, increased muscle glucose absorption, and unchanged glucose tolerance.
- Mice with obesity improved glucose tolerance, improved fatty liver, reduced blood lipids, and reduced fat accumulation.
- After one month of medication, obese mice that ate the same food and did not exercise was 12% lighter than obese mice that did not take the drug.
SLU-PP-332 did not affect the mice’s appetite, nor did it lead them to exercise more. But it activated the metabolic pathways that respond to exercise, allowing the body to consume more energy and metabolize fat more quickly. Overall, SLU-PP-332 can improve fatty acid burning and reduce fat mass, making it potentially useful in the treatment of metabolic illnesses such as obesity and type 2 diabetes.
Potential Benefits of SLU-PP-332
The study on SLU-PP-332 is ongoing; nevertheless, some existing research has demonstrated its potential benefits.
①Alleviate Metabolic Syndrome
SLU-PP-332 possesses exercise-mimicking action and significantly reduced obesity and enhanced insulin sensitivity in a rat model of obesity and metabolic syndrome, suggesting that it could be a viable treatment for both conditions.
Source: https://pubmed.ncbi.nlm.nih.gov/37739806/
②Enhance Exercise Capacity
SLU-PP-332 increases cellular respiration and mitochondrial activity in skeletal muscle cell lines. It also produces an acute aerobic exercise gene program unique to ERRα, which improves exercise endurance in mice.
Source: https://pubmed.ncbi.nlm.nih.gov/36988910/
③Improve Heart Failure
ERRγ is a major mediator of ERR agonism-induced transcriptional regulation and cardioprotection and clearly shows targeting specificity. In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy.
Source: https://pubmed.ncbi.nlm.nih.gov/37961903/
④Reverse Mitochondrial Function and Inflammation in the Aging Kidney
ERR is reduced in both aging human and mouse kidneys, whereas ERR remains unchanged in aging mice subjected to lifelong caloric restriction (CR). Eight weeks of treatment with SLU-PP-332 reversed age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines.
Source: https://pubmed.ncbi.nlm.nih.gov/37717940/
What Are the Side Effects of SLU-PP-332?
SLU-PP-332 has only been tested on mice on a small scale so far, and no serious side effects have been found in the mouse experiments. To determine how much side effects this drug has on humans, more animal experiments need to be conducted, and clinical trials on humans should be gradually carried out.
How About Other Exercise Mimetrics Before SLU-PP-332?
①Resveratrol
It is relatively safe drug, but it is considered to have no clinical value for the weak effect.
②Phenformin
It was found to have a very rare but fatal side effect of lactic acidosis. Moreover, It will have adverse effect on high energy demand organ like heart, because it inhibits mitochondrial ATP production.
③GW501516
It is difficult to metabolize and eliminate as the long half-life, and it will even accumulate in the body. Therefore, it is abandoned.
④AICAR
It is another exercise-mimicking medication that has been examined a lot. AICAR can reduce fat storage, lower insulin resistance, and stimulate gene expression relevant to oxidative metabolism in muscle cells. A study published in Cell in 2008 found that inactive mice treated with AICAR for four weeks increased their running endurance by 44%. Nonetheless, it will bring some severe side effects, including hyperuricemia, hypoglycemia, anemia, thrombocytopenia, nephrotoxicity and hypotension.
Where to Buy SLU-PP-332?
SLU-PP-332 is available from various channels, making it accessible for researchers and institutions interested in studying its effects. When sourcing SLU-PP-332, it is essential to verify the supplier’s credentials and ensure that the products meets the necessary quality standards for your research.
AASraw are supplying pure SLU-PP-332, which is manufactured under strict quality control standards to ensure purity and potency. Additionally, AASraw provides fast and discreet shipping to customers worldwide, making it easy to get the products you need quickly and conveniently. Both small order and bulk buy are available!
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Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine
Scientific Journal paper Author:
1.Nanthini Sadasivam
Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea
2. Fatima Massare Somers
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA
3. Sophie R. Debs
Preclinical Neuropsychiatry Laboratory, Neuroscience Research Australia, Sydney, Australia
4.Woo-Ram Park
Host-Directed Antiviral Research Center, Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Republic of Korea
5.Trine Lund-Jacobsen
BSN, MSc, PhD student, Department of Endocrinology and Metabolism, Centre for Cancer and Organ Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.
