Melanotan II

What is Melanotan II?

Melanotan II (also referred to as Melanotan 2, MT2, MT-2, MT-II) is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis, a process responsible for pigmentation of the skin. Alpha-Melanocyte Stimulating Hormone, often known as MSH, works by activating specific melanocortin receptors to produce its effects. Indeed, through these melanocortin receptors, MSH also has a significant impact on lipid metabolism, hunger, and sexual drive. As a result, investigations have revealed that Melanotan 2 has effects that go beyond just boosting skin tanning, such as suppressing hunger, promoting lipolysis, and enhancing libido. Due to its ability to stimulate melanogenesis, Melanotan 2 has been thoroughly studied for application in preventing the damaging effects of UV radiation from sunshine.

The development of Melanotan 2

The initial creation of the synthetic Melanotan 2 peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, the focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1 and Melanotan 2, which exhibit similar effects whilst possessing an extended half-life for functional therapeutic utilization.

What is Melanin?

Melanin is the skin pigment produced that protects our skin from the sun’s UV radiation and damage. It could be considered our body’s own natural sunscreen. Low levels of melanin mean that the skin is highly susceptible to DNA damage with excess sun exposure. This lack of melanin and its protection against UV radiation means that those individuals with fair skin have a propensity to burn and risk more DNA damage. It also means that a lot of time is invested in their ability to develop a tan safely without burning.

Receiving an adequate supply of vitamin D from the sun without being at risk of developing melanoma is somewhat of a balancing act. Studies have already discovered that staying out of the sun to prevent melanoma can cause vitamin D deficiency. Melanotan II increases melanin production via the stimulation of skin pigment cells called melanocytes.

How does Melanotan II work?

Melanotan II (MT2) works by interacting with specific receptors in the body called melanocortin receptors. Here’s a breakdown of how Melanotan II functions:

Binding to melanocortin receptors

Melanotan II binds to and activates melanocortin receptors, particularly the MC1R and MC4R receptors. These receptors are primarily found on melanocytes, specialized skin cells responsible for producing melanin.

Stimulation of melanin production

When Melanotan II binds to melanocortin receptors, it triggers a series of biochemical reactions within melanocytes. This stimulation leads to increased production of melanin, the pigment responsible for determining skin, hair, and eye color.

Activation of melanin pathways

Melanotan II activates signaling pathways involved in melanogenesis, the process of melanin synthesis. This includes the cyclic adenosine monophosphate (cAMP) pathway, which plays a crucial role in regulating melanin production and distribution.

Increased melanocyte activity

Melanotan II promotes the proliferation and activity of melanocytes, leading to an increase in melanin production. This results in the darkening of the skin and can mimic the effects of natural tanning.

Sun protection effects

By increasing melanin production, Melanotan II can offer some degree of protection against UV radiation. Melanin absorbs UV rays, preventing them from penetrating deeper into the skin layers and causing DNA damage, sunburn, and other harmful effects associated with excessive sun exposure.

It’s important to note that the effectiveness and duration of Melanotan II’s tanning effects may vary among individuals due to factors such as genetics, dosage, and frequency of use. Additionally, while Melanotan II may provide some level of sun protection, it is not a substitute for proper sun protection measures, such as wearing sunscreen and limiting UV exposure.

Melanotan II (MT2) tanning peptide benefits

Melanotan II (MT2) has several special aspects that set it apart from other tanning and skin pigmentation methods. Here are some notable features:

Increased melanin production

Melanotan II is designed to stimulate the production of melanin, the pigment responsible for skin, hair, and eye color. This peptide binds to melanocortin receptors, triggering the release of melanin, which leads to skin darkening.

Potentially reduced sun exposure (Melanotan II for tanning)

One of the significant benefits of Melanotan II is its potential to reduce the amount of sun exposure required to achieve a tan. By stimulating melanin production, it can offer a tanned appearance with less time spent in the sun, minimizing the risk of sunburn and related skin damage.

Melanotan II allows those who never tan and constantly burn in the sun to get a natural tan. Synthetic melanotropin peptide supplements provide a life-changing potential for patients with sun allergies/mutated receptors. A natural tan that develops over time is the strongest cancer defense that fair skin can today achieve. Melanotan was created with the goal of lowering cancer rates and perhaps becoming an effective sunless tanning agent.

Athletes and fitness enthusiasts use Melanotan 2 for accelerated tanning, libido increase, and appetite suppression. Melanotan 2 was dubbed the Barbie drug and has been highlighted in Wired magazine. Synthetic melanocortin therapy helps attain a tan with the least amount of exposure to harmful ultraviolet radiation. Melanotan II continues to be the most effective tanning peptide sold online. Please make sure you buy MT2 from a reliable peptide Manufacturer because poorly made products may carry additional risks.

Potential medical applications

Beyond cosmetic tanning, Melanotan II shows promise in certain medical conditions. For example, it may be used as a treatment option for individuals with vitiligo, a skin disorder characterized by patches of depigmented skin. Additionally, it has been studied for its potential effectiveness in managing erythropoietic protoporphyria (EPP), a rare inherited disorder that causes severe sensitivity to sunlight.

Reported libido enhancement

An interesting aspect associated with Melanotan 2 is its reported effects on libido and sexual function. Some users have reported increased sexual arousal and desire as a potential side effect of using this peptide. However, it’s important to note that these effects are anecdotal and may not be experienced by all users.

Melanotan II weight loss

While not its primary purpose, some studies have suggested that Melanotan II may contribute to appetite suppression and weight loss. However, further research is needed to fully understand its effects on metabolism and weight regulation.

The available form of Melanotan II (MT2) in the market

There are many Melanotan II for sale online, and the supply of MT2 is huge.MT2 has available form in Nasal sprays,pre-mixed Melanotan 2, pills, oral melanotan2, and Melanotan II injections. However, peptide Melanotan II (MT2) is primarily available in the market in the form of lyophilized powder for reconstitution and subsequent administration. Here are the most common forms of Melanotan II available:

Powder Form

Melanotan II is typically sold as a lyophilized powder, which is a freeze-dried form of the peptide. It usually comes in vials or small containers. Melanoan 2 supplier AASRAW not only supplies raw powder from peptides but also lyophilized powder in vials.

Reconstitution

Before use, the powder needs to be reconstituted with a suitable solvent, typically sterile water or bacteriostatic water. Reconstitution instructions may vary depending on the specific product and MT2 manufacturer, so it is important to carefully follow the provided guidelines.

Injection

Once the powder is reconstituted, Melanotan II is usually administered via subcutaneous injection. A small needle is used to inject the solution under the skin, typically in the fatty tissue of the abdomen or thigh. Instead of buying injections in the local country, it saves money for him/her to buy lyophilized powder of Melanotan 2 to make their own MT2 injection. Buy Melanotan 2 wholesale will get a decent price.

It’s crucial to ensure the quality and legitimacy of the product when buying Melanotan II, as counterfeit or improperly manufactured versions can pose additional risks.

Melanotan II Side Effects

Melanotan II peptide given subcutaneously is reported safe and efficacious in recommended dosages. Side effects reported with Melanotan II include :

Nausea

Stomach aches

Decreased appetite

Yawning

Darkened skin

Spontaneous penile erections

Change in mole shapes

In more serious cases, there are potential risks for these far more serious side effects, including:

A serious form of skin cancer (melanoma)

Creation of new moles and atypical melanocytic naevi

Rhabdomyolysis (destruction of muscle cells that is potentially fatal)

Encephalopathy syndrome

Sexual dysfunction

It’s also vital to understand that if needles are shared or not properly sanitized before use, there’s a risk of contamination. As with any injection, redness, and soreness at the injection site are possible. Only buy peptide Melanotan II with a purity of 98% or higher.

It is NOT recommended to use PT-141 injection concurrently with a PDE5 inhibitor in men due to the risk of priapism.

This product should not be used if you are pregnant or nursing. There is insufficient evidence to demonstrate how safe it is for people in this category. As with any other drug, you should always consult with a medical expert before beginning any supplements. This is especially critical if you are on any other drugs. At this time, there are no known drug interactions, but it’s always better to be cautious than sorry.

Researchers interested in researching Melanotan 2 side effects may be curious about where to buy this research chemical online. Unfortunately, finding a legitimate supplier of research-grade peptides can be challenging.AASRAW is a reliable peptide manufacturer to trust.

Melanotan II Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? 

H Nuclear Magnetic Resonance (INMR)spectroscopy is an analytical chemistry technique used in quality control
and research for determining the content and purity of a sample as well as its molecular structure. For 
example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR 
can(either be used to match against spectral libraries or to infer the basic structure directly. Once the
basic structure is known, NMR can be used to determine molecular conformation in solution as well as 
studying physical properties at the molecular level such as conformational exchange, phase changes,
solubility, and diffusion.

How to buy Melanotan II from AASraw?

❶To contact us by our email inquiry system, or leave your WhatsApp number to us, our customer service representative(CSR) will contact you in 12 hours.

❷To provide us with your inquired quantity and address.

❸Our CSR will provide you with the quotation, payment term, tracking number, delivery ways, and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Mariël P Ter Laak
Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
2. Chase W. Mallory BHS
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
3. Miia Kilpeläinen
School of Pharmacy, Pharmaceutical Technology, University of Eastern Finland, Kuopio, Finland
4. Ryouichi Banno
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Japan
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1] Gilhooley E, Daly S, McKenna D.”Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.”Dermatology. 2021;237(6):995-999. doi: 10.1159/000514492. Epub 2021 Aug 31.PMID: 34464955

[2] Peters B, Hadimeri H, Wahlberg R, Afghahi H.”Melanotan II: a possible cause of renal infarction: review of the literature and case report.”CEN Case Rep. 2020 May;9(2):159-161. doi: 10.1007/s13730-020-00447-z. Epub 2020 Jan 18.PMID: 31953620

[3] Tomassi S, Dimmito MP, Cai M, D’Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S.”CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.”J Med Chem. 2022 Mar 10;65(5):4007-4017. doi: 10.1021/acs.jmedchem.1c01848. Epub 2022 Feb 21.PMID: 35188390

[4] Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J.”Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat.”Neuroscience. 2006;138(1):293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19.PMID: 16360286

[5] Hjuler KF, Lorentzen HF.”Melanoma associated with the use of melanotan-II.”Dermatology. 2014;228(1):34-6. doi: 10.1159/000356389. Epub 2013 Dec 18.PMID: 24355990

[6] Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.”Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.”Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366. doi: 10.1152/ajpendo.00024.2018. Epub 2018 May 29.PMID: 29812984

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