Sunifiram, Sunifiram: Exploring the Top 7 Nootropics (Smart Drugs) Available in the Market, aasrww.com


Sunifiram ( DM-235 ) is an experimental drug that acts as a positive allosteric modulator of the AMPA receptor, 1 which has been shown to have nootropic effects in animals with a significantly higher potency than that of piracetam. A series of related compounds are known, one being the unifiram (DM-232).


1.Sunifiram powder 314728-85-3 Chemical properties
2.Sunifiram (314728-85-3) is a nootrop or a drug.
3.Sunifiram (dm 235) – what kind of nootropic, what is its principle of action, dosages, reviews
4.Sunifiram powder Dosage
5.What effect does Sunifiram have?
6.Where and in what form is it used Sunifiram?
7.What are the side effects of Sunifiram?
8.Which Sunifiram experience is known?

1. Sunifiram powder 314728-85-3 Chemical properties

CAS Number: 314728-85-3
Formula C14H18N2O2
Molar mass 246.304 g/mol

2. Sunifiram (314728-85-3) is a nootrop or a drug.

Nootropic drugs gradually, but surely, are part of our life-filled, stressful life. Today they are represented in a wide variety, with many being at the stage of development and research, while others are unknown.
Nootropic drugs gradually, but surely, are part of our life-filled, stressful life. Today they are represented in a wide variety, with many being at the stage of development and research, while others are unknown. The black market is full of nootropics, because the demand for them is growing – people have always wanted to use the reserves of the brain to the maximum.

Many drugs of this group can not be imported into Russia and sold. But the forbidden does not mean bad. A vivid example of such a tool is Sunfiram (prohibited for importation). According to official information, he has not yet passed sufficient number of necessary tests on people. Nevertheless, the results of scientific research available at the moment allow us to draw conclusions about its high efficiency.

Many people have already experienced the effect of Sunifiram. Some have completely solved health problems. Judging by the experimental data and conclusions of the scientists, the drug does not cause side effects, so even if it is not possible to eliminate the disease, then, at least, it will be possible to stop its development without harming the body. In this article I would like to reveal the peculiarities of using Sunfire on the basis of information received at the forums, and talk about the possibility and impossibility of its purchase on the Russian market.

3. Sunifiram (dm 235) – what kind of nootropic, what is its principle of action, dosages, reviews

Sunfyram (chemical formula C14H18N2O2) is a derivative of a pyracetam compound synthesized. It has the same effect as the rest of the racetamen, but is more powerful and less toxic than the precursor. The main course of action of dm-235 is the activation of AMPA receptors, which ensure the production of the neurotransmitter glutamate, in connection with which it is classified as ampakines.
Glutamate plays a key role in the state of the cognitive sphere, its deficiency leads to memory loss, learning difficulties, inability to concentrate, etc. In animal studies, it has been shown that even with the artificial blocking of AMPA receptors, sunifirum stimulates sufficient production of glutamate in the central nervous system.

In addition, like the rest of the ratsetam, Sunifiram increases the activity of cholinergic receptors. As a result, the effect of the drug leads to such effects as:

• facilitates memorization;
• supports the structure of the central nervous system during periods of increased mental stress;
• improves the transmission of impulses between neurons;
• controls the vital activity of brain cells;
• normalizes and enhances metabolism in the brain;
• increases attention, concentration, exacerbates vigilance and perception;
• contributes to improving the relationship between the hemispheres and so on.

Approved instructions for the application of Sunifiram no. The drug is administered in a single dose of 10-50 mg. In practice, the working dose of dm-235 is at least 30 mg sublingually. In general, it is necessary to take into account that the experience of applying nootropics is rather small, in comparison with foreign users. Therefore, it is necessary to listen with care to the majority of “councils”.

Sunifiram, Sunifiram: Exploring the Top 7 Nootropics (Smart Drugs) Available in the Market, aasrww.com

4. Sunifiram powder Dosage

The appropriate oral dose of Sunifiram needed may vary depending on the conditions of use, for cognitive impairment it is 2.4-4.8g daily.

5. What effect does Sunifiram have?

drugs have an effect in that they trigger a change in the transmission of messenger substances and form nerve cells from certain stem cells. The different preparations prove their effectiveness on the central nervous system by causing positive changes in the brain. They increase concentration and memory and increase motivation and mood. This is why Sunifiram have long been known in Germany and are used for various purposes, including anti-aging and wellness. Sunifiram are legal and can be purchased in pharmacies or from appropriate online providers.

Since the specific effect of individual preparations differs from others, the appropriate agent should be selected before the start of treatment. While some products encourage creativity, other supplements increase intelligence. With the right Sunifiram drug you can achieve specific effects and, depending on your individual needs, provide more motivation and concentration, or build up a higher resistance to stress and counteract memory deficiency.

6. Where and in what form is it used Sunifiram?

The drugs are mainly offered in capsule form for oral use and are almost without side effects, as the ingredients are virtually non-toxic. A Sunifiram list makes it easy to find the right preparation for each therapy.

7. What are the side effects of Sunifiram?

If taken prescriptively, you do not have to expect side effects. However, over time, the body builds tolerance to the drug. After prolonged ingestion gradually diminishes the effect. Therefore, treatment should not take longer than recommended in the package leaflet. At higher doses, the agents have a stimulating effect, which may cause mild palpitations or discomfort.

8. Which Sunifiram experience is known?

Most users reported a reliable effect of the preparations and described their Sunifiram experience as good. With the substance, learning ability and memory can be improved in everyday life. In addition, the preparations have a positive influence in coping with stressful situations. They protect the brain from physical and psychological attacks caused by drugs or barbiturates.

The preparations themselves have no stimulating and anesthetic effects. Therefore, most users used the products in their daily lives without any consequences. In pharmacology, the agents are also referred to as neuro-enhancers or smartpills used to maintain and enhance intellectual performance. However, the products are mainly used as a therapy for diseases that reduce the brain activity. In these areas, the mode of action has been proven for a long time and users report invariably good results.

In the meantime, more and more healthy people are also resorting to the means to better master work and everyday life through a higher mental capacity. Using a Sunifiram powder list, every consumer will find the preparation that best suits their purpose. A secure effect possesses the substance with regard to the increase in concentration. For this reason, many consumers claimed to use the product as a “brain doping” in high stress during study or at work. The medicines, in addition to better coping with stressful situations, have other health aspects as well. They increase creativity and help with difficult decisions and reduce premature actions. In addition, sleep patterns change, contributing to improved recovery.

AASraw is the professional manufacturer of Sunifiram powder which has independent lab and large factory as support, all production will be carried out under CGMP regulation and trackable quality control system. The supply system is stable, both retail and wholesale orders are acceptable.Welcome to learn more information about AASraw!

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Author of this article:

Dr. Monique Hong graduated  from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:

1.Shigeki Moriguchi

Department of Pharmacology, Graduate School of  Pharmaceutical Sciences, Tohoku University, Sendai, Japan

2.Elisabetta Martini

Department of Pharmaceutical Sciences, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy

3.Monica Norcini

Department of Preclinical and Clinical Pharmacology, University of Florence Viale Pieraccini 6, 50139 Firenze, Italy

4.Serena Scapecchi

Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, I-50121 Firenze, Italy

5.Khalid A Agha

Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

6.M N Romanelli

Dipartimento di Scienze Farmaceutiche, University of Florence, Sesto Fiorentino, Italy.

In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

References

[1] Shigeki Moriguchi, Tomoya Tanaka, Hideaki Tagashira, Toshio Narahashi, Kohji Fukunaga.”Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.”https://doi.org/10.1016/j.bbr.2012.12.054 [2] Elisabetta Martini, Alberto Salvicchi, Carla Ghelardini, Dina Manetti, Silvia Dei, Luca Guandalini, Cecilia Martelli, Michele Melchiorre, Cristina Cellai, Serena Scapecchi, Elisabetta Teodori, Maria Novella Romanelli. “Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.”https://doi.org/10.1016/j.bmc.2009.08.055 [3] Elisabetta Martini, Monica Norcini, Carla Ghelardini, Dina Manetti, Silvia Dei, Luca Guandalini, Michele Melchiorre, Simona Pagella, Serena Scapecchi, Elisabetta Teodori, Maria Novella Romanelli.”Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.”https://doi.org/10.1016/j.bmc.2008.10.017 [4] Serena Scapecchi, Elisabetta Martini, Dina Manetti, Carla Ghelardini, Cecilia Martelli, Silvia Dei, Nicoletta Galeotti, Luca Guandalini, Maria Novella Romanelli, Elisabetta Teodori.”Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs.”https://doi.org/10.1016/j.bmc.2003.10.025 [5] Agha KA, Abo-Dya NE, Issahaku AR, Agoni C, Soliman MES, Abdel-Aal EH, Abdel-Samii ZK, Ibrahim TS.”Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening.”J Enzyme Inhib Med Chem. 2022 Dec;37(1):1241-1256. doi: 10.1080/14756366.2022.2068147.PMID: 35484855 [6] Romanelli MN, Galeotti N, Ghelardini C, Manetti D, Martini E, Gualtieri F.”Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers.”CNS Drug Rev. 2006 Spring;12(1):39-52. doi: 10.1111/j.1527-3458.2006.00039.x.PMID: 16834757 [7] Moriguchi S, Tanaka T, Narahashi T, Fukunaga K.”Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.”Hippocampus. 2013 Oct;23(10):942-51. doi: 10.1002/hipo.22150. Epub 2013 Jul 16.PMID: 23733502 [8] Ghelardini C, Galeotti N, Gualtieri F, Romanelli MN, Bucherelli C, Baldi E, Bartolini A.”DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer.”Naunyn Schmiedebergs Arch Pharmacol. 2002 Jun;365(6):419-26. doi: 10.1007/s00210-002-0577-3. Epub 2002 May 15.PMID: 12070754 [9] Moriguchi S, Tanaka T, Tagashira H, Narahashi T, Fukunaga K.”Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.”Behav Brain Res. 2013 Apr 1;242:150-7. doi: 10.1016/j.bbr.2012.12.054. Epub 2013 Jan 4.PMID: 23295391 [10] Gualtieri F.”Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings.”J Enzyme Inhib Med Chem. 2016;31(2):187-94. doi: 10.3109/14756366.2015.1021252. Epub 2015 Apr 1.PMID: 25831025 [11] Galeotti N, Ghelardini C, Pittaluga A, Pugliese AM, Bartolini A, Manetti D, Romanelli MN, Gualtieri F.”AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram).”Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45. doi: 10.1007/s00210-003-0812-6. Epub 2003 Nov 5.PMID: 14600801 [12] Martino MV, Guandalini L, Di Cesare Mannelli L, Menicatti M, Bartolucci G, Dei S, Manetti D, Teodori E, Ghelardini C, Romanelli MN.”Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents.”Bioorg Med Chem. 2017 Mar 15;25(6):1795-1803. doi: 10.1016/j.bmc.2017.02.019. Epub 2017 Feb 16.PMID: 28238510 [13] Guandalini L, Martino MV, Di Cesare Mannelli L, Bartolucci G, Melani F, Malik R, Dei S, Floriddia E, Manetti D, Orlandi F, Teodori E, Ghelardini C, Romanelli MN.”Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.”Bioorg Med Chem Lett. 2015 Apr 15;25(8):1700-1704. doi: 10.1016/j.bmcl.2015.03.009. Epub 2015 Mar 12.PMID: 25813160 [14] Guandalini L, Martini E, Di Cesare Mannelli L, Dei S, Manetti D, Scapecchi S, Teodori E, Ghelardini C, Romanelli MN.”Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.”Bioorg Med Chem Lett. 2012 Mar 1;22(5):1936-9. doi: 10.1016/j.bmcl.2012.01.045. Epub 2012 Jan 25.PMID: 22325944 [15] Manetti D, Ghelardini C, Bartolini A, Dei S, Galeotti N, Gualtieri F, Romanelli MN, Teodori E.”Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity.”J Med Chem. 2000 Nov 16;43(23):4499-507. doi: 10.1021/jm000972h.PMID: 11087574
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