Anastrozole powder

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What is Anastrozole powder?

Anastrozole, also known as Arimidex, is a medicine that contains the active substance anastrozole. It is used to treat breast cancer in women who have already gone through menopause. Arimidex belongs to a group of medicines called ‘aromatase inhibitors’ which reduce the amount of the hormone estrogen made in the body by blocking the action of an enzyme in the body called ‘aromatase.Decreasing the production of estrogen is a way of suppressing the growth of breast cancer because the growth of breast tissue is stimulated by estrogen.

What does Arimidex do to the body?

Estrogen is a hormone that plays a key role in the growth and development of breast cancer. It is produced in the body by an enzyme called aromatase, which converts androgens (male hormones) into estrogen. By blocking the activity of aromatase, Arimidex reduces the amount of estrogen in the body, which can slow or stop the growth of breast cancer cells.

In addition to its use in breast cancer treatment, Arimidex has also been used off-label to treat infertility in women with ovulatory disorders. In these cases, Arimidex can help to stimulate ovulation by reducing the levels of estrogen in the body, which can interfere with the normal hormonal balance required for ovulation.

The use of Arimidex can have several effects on the body, some of which are beneficial and some of which can be potentially harmful. Some of the most notable effects of Arimidex include:

Reduced risk of breast cancer recurrence: Arimidex has been shown to be effective in reducing the risk of breast cancer recurrence in postmenopausal women with hormone receptor-positive breast cancer. In clinical trials, Arimidex has been shown to be more effective than tamoxifen, another commonly used breast cancer drug, in reducing the risk of recurrence.

Bone loss: One of the potential side effects of Arimidex is bone loss, which can increase the risk of osteoporosis and bone fractures. Estrogen plays an important role in maintaining bone density, and by reducing estrogen levels, Arimidex can accelerate bone loss. To minimize the risk of bone loss, women taking Arimidex may be advised to take calcium and vitamin D supplements, as well as engage in weight-bearing exercise.

Hot flashes: Arimidex can cause hot flashes and other menopausal symptoms, such as vaginal dryness and mood changes. These symptoms are caused by the reduction in estrogen levels and can be managed with lifestyle changes, such as dressing in layers and avoiding triggers like caffeine and alcohol, as well as medications like antidepressants and hormone replacement therapy.

Cardiovascular effects: Arimidex may have a beneficial effect on cardiovascular health by reducing the risk of heart disease and stroke. Estrogen has a protective effect on the cardiovascular system, and by reducing estrogen levels, Arimidex may increase the risk of these conditions. However, studies have shown that Arimidex may have a neutral or even beneficial effect on cardiovascular health, particularly in women who are at high risk for these conditions.

Joint pain: Arimidex can cause joint pain and stiffness, particularly in the hands and wrists. This side effect is thought to be caused by the reduction in estrogen levels, which can affect the production of collagen in the joints. To manage joint pain, women taking Arimidex may be advised to engage in gentle exercises, such as yoga or swimming, and may be prescribed pain medications or anti-inflammatory drugs.

In conclusion, Arimidex is a medication that is primarily used to treat breast cancer in postmenopausal women. It works by blocking the production of estrogen in the body, which can slow or stop the growth of breast cancer cells.

The most common side effects of Arimidex powder

Arimidex powder can produce a variety of adverse effects, some more prevalent than others. These adverse effects may be brief, lasting only a few days to a few weeks. However, if the adverse effects persist, concern you, or become severe, consult your doctor or pharmacist.

These are only a handful of the most prevalent negative effects reported by Arimidex powder users in clinical trials. These adverse effects might vary based on the ailment being treated by the medicine.

More common side effects in people taking Arimidex for early breast cancer include:

●hot flashes

●weakness

●arthritis

●general pain

●joint pain

More common side effects in people taking Arimidex for locally advanced or metastatic breast cancer include:

●hot flashes

●nausea

●weakness

●general pain

●headache

Arimidex Dosage

The dose of Arimidex is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Arimidex should be continued until tumor progression. Arimidex can be taken with or without food.

For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, ARIMIDEX was administered for five years.

No dosage adjustment is necessary for patients with renal impairment or for elderly patients.

What do you need to know before you take Arimidex powder?

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before taking Arimidex

●if you still have menstrual periods and have not yet gone through menopause.

●if you are taking a medicine that contains tamoxifen or medicines that contain estrogen (see the section called ‘Other medicines and Arimidex’).

●if you have ever had a condition that affects the strength of your bones (osteoporosis).

●if you have problems with your liver or kidneys.

If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Arimidex.

If you go into the hospital, let the medical staff know you are taking Arimidex.

Other medicines and Arimidex

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Arimidex can affect the way some medicines work and some medicines can have an effect on Arimidex.

Do not take Arimidex if you are already taking any of the following medicines:

●Certain medicines used to treat breast cancer (selective estrogen receptor modulators),e.g.medicines that contain tamoxifen. This is because these medicines may stop Arimidex from working properly.

●Medicines that contain estrogen, such as hormone replacement therapy (HRT).

If this applies to you, ask your doctor or pharmacist for advice.

Tell your doctor or pharmacist if you are taking the following:

●A medicine is known as an ‘LHRH analog’.This includes gonadorelin, buserelin, goserelin, leuprorelin, and triptorelin. These medicines are used to treat breast cancer, certain female health (gynecological) conditions, and infertility.

Pregnancy and breast-feeding

Do not take Arimidex if you are pregnant or breastfeeding. Stop Arimidex if you become pregnant and talk to your doctor.

Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

Arimidex is not likely to affect your ability to drive or use any tools or machines. However, some people may occasionally feel weak or sleepy while taking Arimidex. If this happens to you, ask your doctor or pharmacist for advice.

Arimidex contains lactose

Arimidex contains lactose which is a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

Anastrozole vs.Letrozole

●Anastrozole and letrozole are both aromatase inhibitors and anti-cancer medications used for treating postmenopausal women with breast cancer.

●The brand name for anastrozole is Arimidex and the brand name for letrozole is Femara. Both drugs are available in generic form.

●Side effects of anastrozole and letrozole that are similar include nausea, vomiting, and headache.

●Side effects of anastrozole that are different from letrozole include hot flashes, pain, arthritis, increased blood pressure, depression, bone pain, weakened bones, sleeplessness,and rash.

●Side effects of letrozole that are different from anastrozole include fatigue, muscle aches, diarrhea, constipation, and chest pain.

●Both anastrozole and letrozole should not be used with tamoxifen because tamoxifen can reduce anastrozole and letrozole levels in the body and decrease their therapeutic effects.

How to store Anastrozole(Arimidex) powder?

Do not store above 30°C.

Keep Arimidex powder out of the sight and reach of children. Keep in a safe place where children cannot see or reach.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Where to buy Anastrozole(Arimidex) powder?

Arimidex powder, a potent and selective aromatase inhibitor used in the treatment of estrogen-receptor-positive breast cancer, can be sourced from a variety of reliable online suppliers. One such Arimidex supplier is AASraw, a reputable manufacturer that specializes in high-quality raw materials and chemical compounds. With a dedication to stringent quality control and adherence to industry standards, AASraw ensures that customers receive only the finest products for their health needs. By choosing to purchase Arimidex powder from AASraw, buyers can enjoy a seamless, secure, and trustworthy shopping experience, while benefiting from the company’s vast knowledge and expertise in the pharmaceutical sector.

If you want to buy Arimidex powder bulk or wholesale, AASRAW is one of the suppliers you don’t want to miss.

Raw Anastrozole(Arimidex) Powder Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as study physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.

Anastrozole powder(120511-73-1)-COA

Anastrozole powder(120511-73-1)-COA

How to buy Anastrozole(Arimidex) Powder from AASraw?

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Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Kevin H. Nguyen
Creighton University School of Medicine, 7500 Mercy Rd, Omaha, NE, 68124, USA
2. Prof Jack Cuzick PhD
Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University London, London, UK
3. Dhairysheel Ghadge
Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, 415020, Maharashtra state, India
4. K. Pather
School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa
5. Maria de Pilar Estevez-Diz
Instituto do Cancer do Estado de Sao Paulo – Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

Reference

[1] Khera M, Adaikan G, Buvat J, Carrier S, El-Meliegy A, Hatzimouratidis K, et al. (December 2016). “Diagnosis and Treatment of Testosterone Deficiency: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015)”. The Journal of Sexual Medicine. 13 (12): 1787–1804. doi:10.1016/j.jsxm.2016.10.009. PMID 27914560.

[2] Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, et al. (2005). “Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer”. Lancet. 365 (9453): 60–2. doi:10.1016/S0140-6736(04)17666-6. PMID 15639680. S2CID 8350282.

[3] Dukes M (1997). “The relevance of preclinical models to the treatment of postmenopausal breast cancer”. Oncology. 54 Suppl 2 (2): 6–10. doi:10.1159/000227748. PMID 9394853.

[4] Sanford M, Plosker GL (2008). “Anastrozole: a review of its use in postmenopausal women with early-stage breast cancer”. Drugs. 68 (9): 1319–40. doi:10.2165/00003495-200868090-00007. PMID 18547136.

[5] Simpson ER (September 2003). “Sources of estrogen and their importance”. The Journal of Steroid Biochemistry and Molecular Biology. 86 (3–5): 225–30. doi:10.1016/S0960-0760(03)00360-1. PMID 14623515. S2CID 11210435.

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