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MOTS-c

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Specification: MOTS-c 5MG, MOTS-c 10MG

AASraw is the professional peptide contract development and manufacturing organization (CDMO) for MOTS-c, providing customized service tailored to meet specific client needs. Welcome to contact with us for more details!

WARNING: This product is for research use only.

 

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Product Description

 

Peptide MOTS-c Basic Characters

Product Name:MOTS-c
CAS:1627580-64-6
Molecular Formula:C101H152N28O22S2
Molecular Weight:2174.62 g/mol
Color:White to off-white
Storage Temp:2℃-8℃

 

For the usage and dosage of MOTS-c, please refer to the professional guidance provided by the original pharmaceutical company. As a professional manufacturer of MOTS-c, AASraw respects and appreciates the research contributions of the original pharmaceutical company and does not provide product usage recommendations.

What is MOTS-c peptide?

MOTS-c, is a mitochondrial-derived peptide (MDP) that is encoded by small open reading frames (sORFs) of the mitochondrial genome. By controlling nuclear genome transcription and mitochondrial metabolism, MOTS-c can help regulate different metabolic homeostases of the body. In recent years, it has garnered a lot of attention because of its possible benefits for disease prevention, anti-aging, and metabolic health.

What is the mechanism of MOTS-c?

MOTS-c may function via several kinds of molecular pathways and plays a physiological role in numerous metabolic disorders. According to studies, MOTS-c affects the occurrence and progression of related metabolic diseases by autocrinely and paracrinely regulating a number of critical metabolic processes, including glucose metabolism, lipid metabolism, and bone metabolism, through the AMPK, AKT, oxidative stress, and inflammation-related pathways.

The potential benefits of MOTS-c

MOTS-c is a 16-amino acid peptide and its main potential benefits include:

  • Regulate insulin sensitivity
  • Reduce fat
  • Improve cardiovascular health
  • Anti-aging
  • Anti-inflammatory

Is MOTS-c safe?

The research stage of MOTS-c is still ongoing. Even though the current tests have not shown any overt adverse effects, further clinical data is still required to assess its safety. Therefore, before beginning any MOTS-c treatment, please be sure you consult a doctor.

MOTS-c and obesity

MOTS-c dramatically reduced obesity in studies using hybrid mice given a high-fat diet (HFD). Additionally, MOTS-c therapy enhanced glucose consumption by improving glucose homeostasis, decreasing hepatic lipid buildup, and promoting AMPK activation and GLUT4 expression in skeletal muscle. In addition to increasing heat generation and calorie intake, MOTS-c helps prevent obesity and hyperinsulinemia brought on by high-fat diets. According to studies, MOTS-c successfully reduces the risk of obesity brought on by a high-fat diet (HFD) by increasing energy expenditure and enhancing insulin sensitivity and glucose metabolism.

MOTS-c and cancer

The most common causes of bone cancer pain are bone destruction and cancer bone metastases. Patients frequently suffer from excruciating pain when they have tumors like lung, prostate, or breast cancer. According to studies, MOTS-c can dramatically lessen the pain and bone loss brought on by cancer in animal models of bone cancer.

According to the study, intraperitoneal injection of MOTS-c could successfully lessen bone cancer pain, and endogenous MOTS-c levels in the BCP mice model were noticeably lower than those in the control group. The AMPK pathway is activated by MOTS-c, and this effect is blocked by substances that inhibit AMPK. Additionally, MOTS-c reduces the generation of inflammatory factors, inhibits microglial activation, and restores mitochondrial biogenesis to decrease neuropathic pain in the spinal cord. Furthermore, it inhibits bone loss and lessens local discomfort by controlling immune cells and osteoclasts in the tumor microenvironment.

The possible stack of MOTS-c

To maximize its effects, MOTS-c can be coupled with a number of other peptides or chemicals, particularly those related to metabolism, muscle growth, fat reduction, and recuperation.

  • CJC-1295 & MOTS-c

Stack MOTS-c with CJC 1295 can optimize growth hormone levels and improves metabolic processes, which leads to fat burning, muscle growth, and better recovery.

  • TB-500 & MOTS-c

TB-500 supports muscle recovery and tissue repair in a synergistic manner, while MOTS-c aids in regulating metabolism and energy utilization

  • AOD-9604 & MOTS-c

AOD-9604 can intensify fat-burning benefits when combined with MOTS-c, making it a potent combo for improving body composition and reducing body fat.

  • IGF-1 LR3 & MOTS-c

Both muscle growth and fat burning can be enhanced by this combo. The effects of IGF1-LR3 on muscle growth are enhanced by MOTS-c’s function in metabolism and energy management.

Note: The above information is for reference only and does not have any guiding significance. Please be sure to seek medical advice before taking any medication.

MOTS-c vs. NAD+

NAD+ (Nicotinamide adenine dinucleotide) is a coenzyme that is essential to many biological processes and found in all living cells. The significance of NAD+ in mitochondrial health, metabolic regulation, and anti-aging has led to comparisons with MOTS-c.

Here is a table to see their difference:

AspectMOTS-cNAD+
 

Characteristics

Peptide derived from mitochondrial DNA (12S rRNA)Coenzyme found in all living cells, derived from Vitamin B3 (Niacin)
Mechanism of ActionActivates AMPK to regulate energy metabolism, promotes mitochondrial biogenesis and fat oxidationFacilitates redox reactions for ATP production, activates sirtuins for DNA repair and stress response
Primary RoleEnhances mitochondrial function, fat oxidation, and muscle recoveryRepair DNA and longevity by activating sirtuins
Effect on MetabolismRegulates energy homeostasis, fat oxidation, and glucose metabolism, especially in muscle cellsIncreases energy production in mitochondria, helps regulate glucose and fat metabolism
Role in AgingHelps delay age-related metabolic dysfunction by improving mitochondrial healthDeclines with age, supplementing NAD+ precursors may support longevity and reverse age-related mitochondrial decline
Impact on ExerciseImproves exercise performance, endurance, and muscle recoverySupports muscle growth and fat burning indirectly

 

MOTS-c is primarily focused on improving muscle recovery, lipid metabolism, and mitochondrial function. NAD+ has a more extensive function in longevity, DNA repair, and cellular metabolism.

Where to buy MOTS-c?

MOTS-c has gained considerable popularity, notably in the fields of metabolic regulation and mitochondrial health. When it comes to MOTS-c, AASraw stands out as a reliable manufacturer with over a decade of experience in the peptide sector. AASraw specializes in offering premium pure MOTS-c, using comprehensive testing and quality control procedures to ensure product potency and authenticity.

How to buy MOTS-c from AASraw?

❶To contact us by our email inquiry system,or leave your whatsapp number to us,our customer service representative(CSR) will contact with you in 12 hours.

❷To provide us your inquired quantity and address.

❸Our CSR will provide you the quotation,payment term,tracking number,delivery ways and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:

1.Byung Soo Kong

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

2.Sandra García-Benlloch

Facultad de Medicina y Odontología, Universidad Católica de Valencia San Vicente Mártir, Spain

3.Toan Pham

The Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

4.Dilara Altay Ozturk 

Department of Physiology, Faculty of Medicine, Malatya Turgut Ozal University, Malatya, Turkey

5.Hiroshi Kumagai
The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA

In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

 

Reference

[1] Kumagai, Hiroshi; Kim, Su-Jeong; Miller, Brendan; Natsume, Toshiharu; Lee, Shin Hyung; Sato, Ayaka; Ramirez, Ricardo; Wan, Junxiang; Mehta, Hemal H; Yen, Kelvin; Cohen, Pinchas (May 2023). “Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein MOTS-c”. Physiology. 38 (S1).

[2] Long YC, Tan TM, Takao I, Tang BL. The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. American journal of physiology Endocrinology and metabolism. 2014;306:E581–591

[3] Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, et al. Humanin: a novel central regulator of peripheral insulin action. PloS one. 2009;4:e6334.

[4] Slavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nature chemical biology. 2013;9:59–64.

[5] D’Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, et al. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY) (2020) 12:5244–58.

[6] Yuan J, Wang M, Pan Y, Liang M, Fu Y, Duan Y, et al. The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats. Sci Rep (2021) 11:20077.

[7] Im SJ, Miller B, Kumagai H, Silverstein AR, Flores M, Yen K. Mitochondrial-derived peptides in aging and age-related diseases. Geroscience (2021) 43:1113–21.

[8] Lu H, Tang S, Xue C, Liu Y, Wang J, Zhang W, et al. Mitochondrial-derived peptide MOTS-c increases adipose thermogenic activation to promote cold adaptation. Int J Mol Sci (2019) 20:2456.

 


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