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DSIP

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Specification: DSIP 5MG, DSIP 10MG

AASraw is the professional peptide contract development and manufacturing organization (CDMO) for DSIP, providing customized service tailored to meet specific client needs. Welcome to contact with us for more details!

WARNING: This product is for research use only.

 

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Product Description

 

Peptide DSIP Basic Characters

Product Name:Delta Sleep Inducing Peptide (DSIP)
CAS:62568-57-4
Molecular Formula:C35H48N10O15
Molecular Weight:848.82 g/mol
Sequence:H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Color:White to off-white
Storage Temp:2℃-8℃

 

For the usage and dosage of DSIP, please refer to the professional guidance provided by the original pharmaceutical company. As a professional manufacturer of DSIP, AASraw respects and appreciates the research contributions of the original pharmaceutical company and does not provide product usage recommendations.

What is DSIP peptide?

DSIP, short for Delta Sleep-Inducing Peptide, is a naturally occurring peptide that is normally generated in the hypothalamus. It targets multiple locations, including several within the brainstem. DSIP was discovered by Swiss scientists in the 1970s while studying the sleep patterns of rabbits. Subsequent studies revealed its potential sleep-inducing properties.

How does DSIP affect sleep?

DSIP is categorized as a neuromodulator and named because of its association with electroencephalogram (EEG) delta waves. In experiments with rabbits, rats, and humans, DSIP’s effect on sleep was primarily through delta waves, whereas in experiments with cats, DSIP primarily affected REM sleep. In addition to sleep, studies have also shown that DSIP may help regulate hormones, neurotransmitters, and even play a role in managing addiction withdrawal symptoms.

Why DSIP can act as a neuromodulator?

Whether a peptide can directly act on the nervous system is closely related to its ability to cross the blood-brain barrier. The blood-brain barrier is a “barrier” between blood vessels and the brain that selectively prevents certain substances from entering the brain from the blood. Usually, it only allows small molecules, non-polar substances and specific carrier proteins to pass through.

It is difficult for most peptides to pass through the blood-brain barrier due to their large molecular weight and complex structure, but studies have found that DSIP can successfully pass through the blood-brain barrier after entering the body. Researchers have demonstrated that DSIP can enter the brain and regulate sleep by directly acting on the nervous system by using methods such as radioimmunoassay (RIA).

The potential benefits of DSIP

According to studies, DSIP has been shown to have the following potential benefits:

  • Improve sleep quality
  • Relieve stress
  • Improve mood
  • Reduce pain
  • Treat withdrawal syndrome

Is DSIP safe?

DSIP is still in the preliminary research stage, and there is not enough information to determine whether DSIP peptide is safe. Although some studies have shown that it is well tolerated by humans without serious side effects, more research is needed to determine the safety of long-term use. If you plan to use DSIP, please seek professional medical advice before use to assess whether it is suitable.

Available forms of DSIP

Common forms of DSIP include:

Lyophilized powder: Lyophilized powder form of DSIP is often used for injection, usually subcutaneous or intramuscular injection.

Oral form: Oral forms of DSIP include capsules, tablets, liquids, etc. However, oral forms of DSIP are easily degraded in the digestive tract, which may reduce its effectiveness.

Solution: DSIP solution is usually placed under the tongue for use. DSIP solution can be directly absorbed into the blood through the sublingual mucosa.

DSIP effectiveness for sleep

Research shows that DSIP can induce a feeling of drowsiness within minutes. In a study with a double-blind crossover design, subjects reported significant sleep pressure after receiving DSIP, and their sleep time increased by 59% within 130 minutes compared with the placebo group. In addition, DSIP did not exhibit typical pharmacological sedative effects and no side effects were observed.

In addition, studies have shown that long-term use of DSIP (several nights in a row) can help improve sleep quality, especially in sleep onset latency (the time it takes to fall asleep) and sleep efficiency (the percentage of actual sleep time). In a study of patients with chronic insomnia, the DSIP group showed shorter sleep onset latency and higher sleep efficiency. Nonetheless, these effects were statistically weak and failed to show significant improvements in other measures. Therefore, short-term use of DSIP to treat chronic insomnia may not be as effective as expected.

Comparison: peptides for sleep

Peptides have a wide range of applications. Although some peptides are not primarily used to improve sleep, they also have potential effects.

Epitalon: a synthetic peptide that promotes deep sleep by regulating the pineal gland’s production of melatonin, which regulates the sleep-wake cycle. It also has anti-aging properties.

Sermorelin: a synthetic peptide that stimulates the natural release of growth hormone, particularly at night. It enhances sleep by improving circadian rhythm and reducing stress hormone levels.

AOD 9604: a synthetic fragment of human growth hormone that promotes fat breakdown and improves cognitive function and sleep.

Here is a table to see their differences:

PeptideBenefitsSide Effects
DSIPImprove sleep quality, stress reduction, improve mood,regulate pain perceptionNA
EpitalonPromote better sleep, anti-aging effects, restore circadian rhythmNausea, headaches, nausea, fatigue, stomach discomfort
SermorelinImprove sleep quality, enhance muscle growth, fat reductionInsulin resistance, injection site pain, headaches, nausea, dizziness
AOD 9604Improve sleep, enhance recovery, fat lossHeadaches, indigestion, nausea, swelling

 

If you want to increase your sleep quality, DSIP is the finest option. If you want to improve your sleep quality while also getting anti-aging, muscle building, and fat reduction advantages, Epitalon, Sermorelin, or AOD 9604 are your options. Please remember to obtain medical advice before using any medications.

Where to buy DSIP?

Synthetic DSIP is very common in the market. Common forms include freeze-dried powder vials, capsules, tablets, etc. Buyers can choose the appropriate form according to their own purposes, but no matter what form of DSIP is purchased, it is necessary to choose a reliable source to ensure that there is no problem with the product quality.

AASraw is a reputable DSIP manufacturer with over ten years of experience with a distinct plant and R&D center. To ensure product quality, all production is done in accordance with GMP rules. Furthermore, each product is extensively verified after production and before going on sale, with test reports such as COA and HPLC. AASraw is an excellent choice for pure DSIP both in raw powder and vial form!

DSIP(62568-57-4)-COA

DSIP(62568-57-4)-COA

How to buy DSIP from AASraw?

❶To contact us by our email inquiry system,or leave your whatsapp number to us,our customer service representative(CSR) will contact with you in 12 hours.

❷To provide us your inquired quantity and address.

❸Our CSR will provide you the quotation,payment term,tracking number,delivery ways and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:

1.Elena M. Khvatova

Nizhnii Novgorod Medical Academy, Minina-Pozharskogo 10/1, 603005, Nizhnii Novgorod, Russian Federation

2.A. Nakamura

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan

3.Koichi Tsunashima

National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Japan

4.M. Vallarino

Institute of Comparative Anatomy, University of Genova, Italy

5.Akihiro Nakamura
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Japan

In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

Reference

[1] Sudakova KV, Umriukhina PE, Rayevskyb KS (2004). “Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors”. Pathophysiology. 11 (2): 81–86.

[2] Graf MV, Hunter CA, Kastin AJ (1984). “Presence of Delta-Sleep-Inducing Peptide-Like Material in Human Milk”Journal of Clinical Endocrinology & Metabolism. 59 (1): 127–32.

[3] Westrin A, Ekman R, Traskman-Bendz L (1998). “High Delta Sleep-Inducing Peptide-Like Immunoreactivity in Plasma in Suicidal Patients with Major Depressive Disorder”. Biological Psychiatry. 43 (10): 734–739.

[4] Charnay Y, Golaz J, Vallet PG, Bouras C (1992). “Production and immunohistochemical application of monoclonal antibodies against delta sleep-inducing peptide”. J Chem Neuroanat. 5 (6): 503–9.

[5] Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II (2003). “Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia”. Peptides. 24 (2): 307–311.

[6] Seifritz E, Muller M, Schonenberger G, Trachsel L, Hemmeter U, Hatzinger M, Ernst A, Moore P, Holsboer-Trachsler E (1995). “Human plasma DSIP decreases at the initiation of sleep at different circadian times”. Peptides. 16 (8): 1475–1481.

[7] Bjartell A, Ekman R, Sundler F, Widerlöv E (1988). “Delta sleep-inducing peptide (DSIP): An overview of central actions and possible relationship to psychiatric illnesses”. Nordic Journal of Psychiatry. 42 (2): 111–117.

[8] Yukhananov RY, Tennila TM, Miroshnichenko II, Kudrina VS, Ushakov AN, Melnik EI (1992). “Ethanol and Delta Sleep Inducing Peptide effects on brain monoamines”.  Biochem. Behav. 43 (3): 683–687.


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